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Proteins/UNIPROT:Q02790
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria..
Function from UniProtKB (Q02790), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
152 statements
152 statements · 4 reference databases · Subject: FKBP4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
17 names
Resolves to: FKBP4
[protein]-peptidylproline (omega=180)[protein]-peptidylproline (omega=0)
Catalysed by PPIH or FKBP9 or PPIB or FKBP2 or PPIF or NKTR or PPIC or PPIA or FKBP1A or FKBP1B or FKBP3 or FKBP4 and 16 more alternatives
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16237CC BY 4.0Reference data