Pathway
G beta:gamma signalling through PLC beta
Phospholipase C beta (PLCbeta) isoforms are activated by G-protein beta:gamma in the order PLCB3 > PLCB2 > PLCB1. Gbeta:gamma binds to the pleckstrin homology domain of PLC beta, increasing phospholipase activity and leading to increased hydrolysis of PIP2 to DAG and IP3.
REACT:R-HSA-418217Reactome
What the reference databases state
Statements
20 statements
20 statements · 1 reference database · Subject: G beta:gamma signalling through PLC beta · Sources: Reactome
- GNB1 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNB2 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNB3 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNB4 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNB5 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG10 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG11 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG12 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG13 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG2 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG3 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG4 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
Show the remaining 8
- GNG5 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG7 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNG8 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNGT1 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- GNGT2 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- PLCB1 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- PLCB2 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only
- PLCB3 participates in G beta:gamma signalling through PLC betaProteinReactome R-HSA-418217Inferred only