Proteins/UNIPROT:O94953

KDM4B

ProteinUNIPROT:O94953Lysine-specific demethylase 4B

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS)..

Function from UniProtKB (O94953), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

complex neurodevelopmental disorder has a germline basis in KDM4BDiseaseGenCC HGNC:29136|MONDO:0100038Inferred only
intellectual developmental disorder, autosomal dominant 65 has a germline basis in KDM4BDiseaseGenCC HGNC:29136|MONDO:0023657Inferred only
syndromic intellectual disability has a germline basis in KDM4BDiseaseGenCC HGNC:29136|MONDO:0000508Inferred only

Statements

42 statements

42 statements · 6 reference databases · Subject: KDM4B · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, UniProt

Order

CRTC1 covaries with KDM4BProteinHetionet hetionet:covaries:23030-23373Inferred only
EFCC1 covaries with KDM4BProteinHetionet hetionet:covaries:23030-79825Inferred only
KDM4B covaries with FGF4ProteinHetionet hetionet:covaries:2249-23030Inferred only
KDM4B is expressed in dorsal motor nucleus of vagus nerveAnatomyBgee ENSG00000127663Inferred only
KDM4B interacts with MED10ProteinHetionet hetionet:interacts:23030-84246Inferred only
UBC interacts with KDM4BProteinHetionet hetionet:interacts:23030-7316Inferred only
KDM4B participates in Chromatin modifying enzymesPathwayReactome R-HSA-3247509Inferred only
KDM4B participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
KDM4B participates in DNA Double Strand Break ResponsePathwayReactome R-HSA-5693606Inferred only
KDM4B participates in DNA Double-Strand Break RepairPathwayReactome R-HSA-5693532Inferred only
KDM4B participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
KDM4B participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only

Show the remaining 30

KDM4B participates in Estrogen-dependent gene expressionPathwayReactome R-HSA-9018519Inferred only
KDM4B participates in HDMs demethylate histonesPathwayReactome R-HSA-3214842Inferred only
KDM4B participates in Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksPathwayReactome R-HSA-5693565Inferred only
KDM4B participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
KDM4B participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
KDM4B regulates regulation of gene expressionBiological processgene ontology O94953|GO:0010468Inferred only
KDM4B decreases the expression of AARS1ProteinHetionet hetionet:regulates:23030-16Inferred only
KDM4B decreases the expression of ANXA4ProteinHetionet hetionet:regulates:23030-307Inferred only
KDM4B decreases the expression of BCL7BProteinHetionet hetionet:regulates:23030-9275Inferred only
CALR increases the expression of KDM4BProteinHetionet hetionet:regulates:811-23030Inferred only
CBR1 decreases the expression of KDM4BProteinHetionet hetionet:regulates:873-23030Inferred only
KDM4B decreases the expression of CHMP4AProteinHetionet hetionet:regulates:23030-29082Inferred only
DCPS increases the expression of KDM4BProteinHetionet hetionet:regulates:28960-23030Inferred only
KDM4B increases the expression of EML3ProteinHetionet hetionet:regulates:23030-256364Inferred only
KDM4B increases the expression of HK1ProteinHetionet hetionet:regulates:23030-3098Inferred only
KDM4B increases the expression of HOOK2ProteinHetionet hetionet:regulates:23030-29911Inferred only
KDM4B increases the expression of MLLT11ProteinHetionet hetionet:regulates:23030-10962Inferred only
KDM4B decreases the expression of PAK4ProteinHetionet hetionet:regulates:23030-10298Inferred only
KDM4B increases the expression of PLCB3ProteinHetionet hetionet:regulates:23030-5331Inferred only
KDM4B decreases the expression of PRSS23ProteinHetionet hetionet:regulates:23030-11098Inferred only
KDM4B decreases the expression of RBM34ProteinHetionet hetionet:regulates:23030-23029Inferred only
KDM4B decreases the expression of RNH1ProteinHetionet hetionet:regulates:23030-6050Inferred only
KDM4B increases the expression of SERPINA3ProteinHetionet hetionet:regulates:23030-12Inferred only
KDM4B decreases the expression of SLC25A6ProteinHetionet hetionet:regulates:23030-293Inferred only
KDM4B increases the expression of STK10ProteinHetionet hetionet:regulates:23030-6793Inferred only
KDM4B decreases the expression of STK25ProteinHetionet hetionet:regulates:23030-10494Inferred only
KDM4B decreases the expression of TXNDC9ProteinHetionet hetionet:regulates:23030-10190Inferred only
KDM4B increases the expression of WIF1ProteinHetionet hetionet:regulates:23030-11197Inferred only
KDM4B requires the cofactor iron(2+)CompoundUniProt O94953Inferred only
formaldehyde is a substrate of KDM4BCompoundRhea RHEA:60200Inferred only

Reactions

1 reaction

N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]+22-oxoglutarate(2-)+2dioxygenN(6)-methyl-L-lysyl(9)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by KDM4F or KDM4E or KDM4A or KDM4B or KDM4D or KDM4C
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60200CC BY 4.0Reference data

Other names

6 names

Resolves to: KDM4B

Also called: [histone H3]-trimethyl-L-lysine(9) demethylase 4BJHDM3BJmjC domain-containing histone demethylation protein 3BJMJD2BJumonji domain-containing protein 2BKIAA0876

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