Pathway
Activation of kainate receptors upon glutamate binding
Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons.
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Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons.
Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin.
REACT:R-HSA-451326Reactome
What the reference databases state
Statements
30 statements
30 statements · 1 reference database · Subject: Activation of kainate receptors upon glutamate binding · Sources: Reactome
- CALM1 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- DLG1 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- DLG3 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- DLG4 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNB1 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNB2 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNB3 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNB4 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNB5 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG10 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG11 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG12 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
Show the remaining 18
- GNG13 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG2 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG3 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG4 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG5 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG7 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNG8 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNGT1 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GNGT2 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GRIK1 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GRIK2 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GRIK3 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GRIK4 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- GRIK5 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- NCALD participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- PLCB1 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- PLCB2 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only
- PLCB3 participates in Activation of kainate receptors upon glutamate bindingProteinReactome R-HSA-451326Inferred only