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Proteins/UNIPROT:Q9P212
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly..
Function from UniProtKB (Q9P212), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
65 statements
65 statements · 9 reference databases · Subject: PLCE1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
water+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycerol+proton+1D-myo-inositol 1-phosphate
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
7 names
Resolves to: PLCE1
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR00663CC BY 4.0Reference data
water+MAM02736ca 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR06559CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCB3 or PLCD3 or PLCB1 or PLCD1 or PLCG2
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11nucleus
Human-GEM MAR08818CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+watera 1,2-diacyl-sn-glycerol+MAM00526c+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR08822CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+water1D-myo-inositol 1,4,5-trisphosphate+a 1,2-diacyl-sn-glycerol+hydron
Catalysed by PLCH2 or PLCG2 or PLCG1 or PLCD1 or PLCB2 or PLCB3 or PLCB4 or PLCH1 or PLCZ1 or PLCD3 or PLCD4 or PLCB1 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33179CC BY 4.0Reference data