ATP1B1

Non-catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. The beta subunit is important for the folding, stability, and targeting of the Na(+)/K(+)-ATPase pump to the plasma membranes (By similarity). In addition, acts as a homotypic cell adhesion molecule in epithelia cells. Interactions between ATP1B1 on neighboring cells are critical for proper lateral polarization of the Na(+)/K(+)-ATPase pump and for stabilizing cell-cell adhesion (By similarity). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1..

Function from UniProtKB (P05026), read 2026-09-23. CC BY 4.0.