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Proteins/UNIPROT:P40926
Mitochondrial malate dehydrogenase that catalyzes the reversible conversion of malate to oxaloacetate using NAD(+) as a cofactor. Plays a central role in the tricarboxylic acid (TCA) cycle contributing to cellular respiration and energy production via the mitochondrial electron transport chain. Also participates in the malate-aspartate NADH shuttle, facilitating transfer of reducing equivalents between cytosol and mitochondria to maintain redox balance (NAD(+)/NADH homeostasis) and support metabolic flux between compartments (By similarity). In addition to its metabolic role, binds to RNA in cells, associating with cytosolic RNAs including tRNAs and mRNAs..
Function from UniProtKB (P40926), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
452 statements
452 statements · 7 reference databases · Subject: MDH2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
3 reactions
proton+NADH(2-)+oxaloacetate(S)-malate+NAD(+)
Catalysed by MDH2
Reaction pageReversibleBalancedEC 1.1.1.37mitochondrial matrix
Human-GEM MAR04141CC BY 4.0Reference data
MAM00179m+NAD(+)MAM00920m+proton+NADH(2-)
Catalysed by MDH2
Reaction pageReversibleBalancedEC 1.1.1.37
1 name
Resolves to: MDH2
Human-GEM MAR08069CC BY 4.0Reference data
(S)-malate+NAD(1-)oxaloacetate+NADH(2-)+hydron
Catalysed by PHGDH or MDH1 or MDH2
Reaction pageReversibleBalanced
Rhea RHEA:21432CC BY 4.0Reference data