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Proteins/UNIPROT:Q9Y6K1
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity)..
Function from UniProtKB (Q9Y6K1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
233 statements
233 statements · 4 reference databases · Subject: DNMT3A · Sources: gene ontology, Hetionet, Reactome, WikiPathways
5 reactions
MAM01721c+S-adenosyl-L-methionineMAM01722c+proton+CHEBI:16680
Catalysed by DNMT1 & DNMT3B or TRDMT1 or DNMT3A or DNMT3L
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37cytosol
Human-GEM MAR04072CC BY 4.0Reference data
MAM01721n+MAM02882nMAM01722n+proton+MAM02881n
5 names
Resolves to: DNMT3A
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37nucleus
Human-GEM MAR08640CC BY 4.0Reference data
MAM01721n+S-adenosyl-L-methionineMAM01722n+proton+CHEBI:16680
Catalysed by DNMT1 & DNMT3B or TRDMT1 or DNMT3A or DNMT3L
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37nucleus
Human-GEM MAR08641CC BY 4.0Reference data
a 2'-deoxycytidine in DNA+S-adenosyl-L-methioninea 5-methyl-2'-deoxycytidine in DNA+S-adenosyl-L-homocysteine+hydron
Catalysed by DNMT1 or DNMT3B or DNMT3A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:13681CC BY 4.0Reference data
L-cysteinyl-[protein]+S-adenosyl-L-methionineS-methyl-L-cysteinyl-[protein]+S-adenosyl-L-homocysteine+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:66544CC BY 4.0Reference data