Proteins/UNIPROT:Q9P1Z3

HCN3

ProteinUNIPROT:Q9P1Z3Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain (By similarity)..

Function from UniProtKB (Q9P1Z3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

29 statements

29 statements · 4 reference databases · Subject: HCN3 · Sources: gene ontology, Hetionet, Reactome, Rhea

Order

HCN3 participates in HCN channelsPathwayReactome R-HSA-1296061Inferred only
HCN3 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
HCN3 participates in Potassium ChannelsPathwayReactome R-HSA-1296071Inferred only
HCN3 regulates regulation of heart rate by cardiac conductionBiological processgene ontology Q9P1Z3|GO:0086091Inferred only
HCN3 regulates regulation of membrane depolarizationBiological processgene ontology Q9P1Z3|GO:0003254Inferred only
HCN3 regulates regulation of membrane potentialBiological processgene ontology Q9P1Z3|GO:0042391Inferred only
HCN3 regulates regulation of SA node cell action potentialBiological processgene ontology Q9P1Z3|GO:0098907Inferred only
HCN3 increases the expression of AMDHD2ProteinHetionet hetionet:regulates:57657-51005Inferred only
HCN3 decreases the expression of BLCAPProteinHetionet hetionet:regulates:57657-10904Inferred only
HCN3 decreases the expression of BLVRAProteinHetionet hetionet:regulates:57657-644Inferred only
HCN3 increases the expression of C2CD2ProteinHetionet hetionet:regulates:57657-25966Inferred only
HCN3 increases the expression of CDK6ProteinHetionet hetionet:regulates:57657-1021Inferred only

Show the remaining 17

HCN3 decreases the expression of CEMIP2ProteinHetionet hetionet:regulates:57657-23670Inferred only
HCN3 decreases the expression of CSRP1ProteinHetionet hetionet:regulates:57657-1465Inferred only
HCN3 increases the expression of DDX42ProteinHetionet hetionet:regulates:57657-11325Inferred only
HCN3 increases the expression of ERAP2ProteinHetionet hetionet:regulates:57657-64167Inferred only
HCN3 decreases the expression of LBRProteinHetionet hetionet:regulates:57657-3930Inferred only
HCN3 increases the expression of MINDY1ProteinHetionet hetionet:regulates:57657-55793Inferred only
HCN3 decreases the expression of P4HA2ProteinHetionet hetionet:regulates:57657-8974Inferred only
HCN3 decreases the expression of PEG10ProteinHetionet hetionet:regulates:57657-23089Inferred only
HCN3 decreases the expression of PIK3C2BProteinHetionet hetionet:regulates:57657-5287Inferred only
HCN3 increases the expression of PLCB3ProteinHetionet hetionet:regulates:57657-5331Inferred only
HCN3 increases the expression of RRS1ProteinHetionet hetionet:regulates:57657-23212Inferred only
HCN3 decreases the expression of TMEM109ProteinHetionet hetionet:regulates:57657-79073Inferred only
HCN3 decreases the expression of TSKUProteinHetionet hetionet:regulates:57657-25987Inferred only
HCN3 decreases the expression of UGDHProteinHetionet hetionet:regulates:57657-7358Inferred only
HCN3 decreases the expression of VAT1ProteinHetionet hetionet:regulates:57657-10493Inferred only
K(+) is transported by HCN3CompoundRhea RHEA:29463Inferred only
sodium(1+) is transported by HCN3CompoundRhea RHEA:34963Inferred only

Reactions

2 reactions

K(+)K(+)
Transported by ANO9 or HTR3E or KCNU1 or KCNJ18 or TMEM150C or KCNK1 or KCNK3 or GRIN2D or KCNN4 or KCNQ3 or KCNQ2 or HCN1 and 136 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29463CC BY 4.0Reference data

Other names

2 names

Resolves to: HCN3

Also called: KIAA1535Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

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