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Proteins/UNIPROT:Q8NHM5
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable)..
Function from UniProtKB (Q8NHM5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
240 statements
240 statements · 6 reference databases · Subject: KDM2B · Sources: Bgee, gene ontology, Hetionet, Reactome, UniProt, WikiPathways
1 reaction
N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3]+22-oxoglutarate(2-)+2dioxygenL-lysyl(36)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by KDM2B or RIOX1 or KDM2A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:42032CC BY 4.0Reference data
16 names
Resolves to: KDM2B