MEST

Plays an important role in enabling neurons to transition from bipolar to multipolar shapes, a process essential for their correct migration toward the cortical plate during brain development. This function is likely achieved through the regulation of N-cadherin-dependent cell adhesion and the modulation of Akt and canonical Wnt signaling pathways. Essential for the development and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. Negatively regulates the canonical Wnt signaling pathway during adipogenic differentiation by reducing the glycosylation, maturation, and cell membrane localization of the Wnt coreceptor LRP6..

Function from UniProtKB (Q5EB52), read 2026-09-23. CC BY 4.0.