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Proteins/UNIPROT:O75223
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis..
Function from UniProtKB (O75223), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
128 statements
128 statements · 6 reference databases · Subject: GGCT · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
gamma-L-glutamyl-L-cysteineCHEBI:18183+L-cysteine
Reaction pageLeft to rightBalancedEC 4.3.2.9cytosol
Human-GEM MAR04708CC BY 4.0Reference data
L-alpha-aminobutyric acid+CHEBI:18183MAM01931c
Catalysed by GGCT
Reaction pageReversibleBalancedEC 4.3.2.9cytosol
Human-GEM MAR06971CC BY 4.0Reference data
3 names
Resolves to: GGCT
CHEBI:18183+CHEBI:16856MAM01928c
Catalysed by GGCT
Reaction pageReversibleBalancedEC 4.3.2.9cytosol
Human-GEM MAR06972CC BY 4.0Reference data
gamma-Glu-AlaCHEBI:18183+L-alanine
Reaction pageLeft to rightBalancedEC 4.3.2.9extracellular space, cytosol
Human-GEM MAR08770CC BY 4.0Reference data
an alpha-(gamma-L-glutamyl)-L-amino acid5-oxo-L-proline+an L-alpha-amino acid
Catalysed by GGCT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20505CC BY 4.0Reference data