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Proteins/UNIPROT:Q99550
Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells. At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation..
Function from UniProtKB (Q99550), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 2 reference databases · Subject: MPHOSPH9 · Sources: gene ontology, Hetionet
2 names
Resolves to: MPHOSPH9