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Proteins/UNIPROT:O94916
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA..
Function from UniProtKB (O94916), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
45 statements
45 statements · 3 reference databases · Subject: NFAT5 · Sources: gene ontology, Hetionet, WikiPathways
6 names
Resolves to: NFAT5