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Proteins/UNIPROT:P23743
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol..
Function from UniProtKB (P23743), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
85 statements
85 statements · 6 reference databases · Subject: DGKA · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
14 reactions
6 names
Resolves to: DGKA
a 1,2-diacyl-sn-glycerol+ATP(4-)a 1,2-diacyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10272CC BY 4.0Reference data
a 1-O-alkyl-sn-glycerol+ATP(4-)a 1-O-alkyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16937CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+ATP(4-)1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40323CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+ATP(4-)1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40327CC BY 4.0Reference data
1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+ATP(4-)CHEBI:77186+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40403CC BY 4.0Reference data
CHEBI:77185+ATP(4-)CHEBI:77187+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40407CC BY 4.0Reference data
1-O-hexadecyl-sn-glycerol+ATP(4-)1-O-hexadecyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalanced
Rhea RHEA:41672CC BY 4.0Reference data
1-O-hexadecyl-2-acetyl-sn-glycerol+ATP(4-)1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalanced
Rhea RHEA:41676CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol+ATP(4-)1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:43416CC BY 4.0Reference data
1,2-didecanoyl-sn-glycerol+ATP(4-)1,2-didecanoyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKG or DGKZ or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:43428CC BY 4.0Reference data
1-O-alkyl-2-acyl-sn-glycerol+ATP(4-)CHEBI:73332+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44072CC BY 4.0Reference data