Loading the page.
Proteins/UNIPROT:Q16698
Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids (Probable). Together with the Enoyl-CoA delta isomerase 1 (ECI1) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Acts primarily on polyunsaturated fatty acids (Probable). Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable)..
Function from UniProtKB (Q16698), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
424 statements
424 statements · 6 reference databases · Subject: DECR1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
31 reactions
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA+CHEBI:1146900+water+NAD(+)(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA+CHEBI:15351+proton+NADH(2-)
Catalysed by ACADL & HADHA & ECI1 & HADHB & ECH1 & DECR1 or ECI2 & ACADL & HADHA & HADHB &
6 names
Resolves to: DECR1
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00970CC BY 4.0Reference data
MAM01199m+proton+NADPH(4-)MAM01200m+NADP(3-)
Catalysed by DECR1
Reaction pageLeft to rightBalancedEC 1.3.1.34mitochondrial matrix
Human-GEM MAR01176CC BY 4.0Reference data
MAM01144m+proton+NADPH(4-)MAM01145m+NADP(3-)
Catalysed by DECR1
Reaction pageReversibleBalancedEC 1.3.1.34mitochondrial matrix
Human-GEM MAR01181CC BY 4.0Reference data
MAM01204m+proton+NADPH(4-)MAM01205m+NADP(3-)
Catalysed by DECR1
Reaction pageLeft to rightBalancedEC 1.3.1.34mitochondrial matrix
Human-GEM MAR01218CC BY 4.0Reference data
MAM01147m+proton+NADPH(4-)MAM01148m+NADP(3-)
Catalysed by DECR1
Reaction pageReversibleBalancedEC 1.3.1.34mitochondrial matrix
Human-GEM MAR01222CC BY 4.0Reference data
proton+NADPH(4-)+MAM03359mNADP(3-)+MAM03360m
Catalysed by DECR1
Reaction pageReversibleBalancedEC 1.3.1.34mitochondrial matrix
Human-GEM MAR03377CC BY 4.0Reference data
MAM00682m+proton+NADPH(4-)NADP(3-)+MAM03034m
Catalysed by DECR1
Reaction pageLeft to rightBalancedEC 1.3.1.34mitochondrial matrix
Human-GEM MAR03446CC BY 4.0Reference data
MAM00072m+proton+NADPH(4-)MAM00089m+NADP(3-)
Catalysed by DECR1
Reaction pageReversibleBalancedEC 1.3.1.34mitochondrial matrix
Human-GEM MAR03457CC BY 4.0Reference data
MAM00678m+proton+NADPH(4-)NADP(3-)+(3E)-decenoyl-CoA
Catalysed by DECR1
Reaction pageLeft to rightBalancedEC 1.3.1.124mitochondrial matrix
Human-GEM MAR04970CC BY 4.0Reference data
proton+NADPH(4-)+(2E,4Z,7Z)-decatrienoyl-CoANADP(3-)+MAM03205m
Catalysed by DECR1
Reaction pageLeft to rightBalancedEC 1.3.1.124mitochondrial matrix
Human-GEM MAR05001CC BY 4.0Reference data
proton+NADPH(4-)+(2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoANADP(3-)+MAM03220m
Catalysed by DECR1
Reaction pageLeft to rightBalancedEC 1.3.1.124mitochondrial matrix
Human-GEM MAR05312CC BY 4.0Reference data
proton+NADPH(4-)+MAM03557mNADP(3-)+MAM03210m
Catalysed by DECR1
Reaction pageLeft to rightBalancedEC 1.3.1.124mitochondrial matrix
Human-GEM MAR05404CC BY 4.0Reference data