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Proteins/UNIPROT:Q86YW0
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function..
Function from UniProtKB (Q86YW0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
14 statements
14 statements · 8 reference databases · Subject: PLCZ1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
water+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycerol+proton+1D-myo-inositol 1-phosphate
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
4 names
Resolves to: PLCZ1
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR00663CC BY 4.0Reference data
water+MAM02736ca 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR06559CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCB3 or PLCD3 or PLCB1 or PLCD1 or PLCG2
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11nucleus
Human-GEM MAR08818CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+watera 1,2-diacyl-sn-glycerol+MAM00526c+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR08822CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+water1D-myo-inositol 1,4,5-trisphosphate+a 1,2-diacyl-sn-glycerol+hydron
Catalysed by PLCH2 or PLCG2 or PLCG1 or PLCD1 or PLCB2 or PLCB3 or PLCB4 or PLCH1 or PLCZ1 or PLCD3 or PLCD4 or PLCB1 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33179CC BY 4.0Reference data