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Proteins/UNIPROT:Q9BRC7
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation..
[Isoform 2]: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G protein) alpha subunit GNAI3..
Function from UniProtKB (Q9BRC7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
36 statements
36 statements · 8 reference databases · Subject: PLCD4 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
water+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycerol+proton+1D-myo-inositol 1-phosphate
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
4 names
Resolves to: PLCD4
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR00663CC BY 4.0Reference data
water+MAM02736ca 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR06559CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCB3 or PLCD3 or PLCB1 or PLCD1 or PLCG2
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11nucleus
Human-GEM MAR08818CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+watera 1,2-diacyl-sn-glycerol+MAM00526c+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR08822CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+water1D-myo-inositol 1,4,5-trisphosphate+a 1,2-diacyl-sn-glycerol+hydron
Catalysed by PLCH2 or PLCG2 or PLCG1 or PLCD1 or PLCB2 or PLCB3 or PLCB4 or PLCH1 or PLCZ1 or PLCD3 or PLCD4 or PLCB1 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33179CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+water1D-myo-inositol 1-phosphate+a 1,2-diacyl-sn-glycerol+hydron
Catalysed by PLCG1 or PLCD1 or PLCB2 or PLCB3 or PLCXD2 or PLCB4 or PLCD4 or PLCB1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:43484CC BY 4.0Reference data