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Proteins/UNIPROT:Q9UKU7
Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA..
Function from UniProtKB (Q9UKU7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
99 statements
99 statements · 8 reference databases · Subject: ACAD8 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
FADH2+MAM02468mFAD+isobutyryl-CoA
Catalysed by ACAD8 or ACADS or ACADSB
Reaction pageReversibleBalancedEC 1.3.8.5, 1.3.8.1mitochondrial matrix
Human-GEM MAR03752CC BY 4.0Reference data
6 names
Resolves to: ACAD8
Reaction pageReversibleBalancedEC 1.3.8.5, 1.3.8.1mitochondrial matrix
Human-GEM MAR03784CC BY 4.0Reference data
propanoyl-CoA+oxidized [electron-transfer flavoprotein]+hydronacryloyl-CoA+reduced [electron-transfer flavoprotein]
Catalysed by ACAD8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:31287CC BY 4.0Reference data
2-methylpropanoyl-CoA+oxidized [electron-transfer flavoprotein]+hydronCHEBI:62500+reduced [electron-transfer flavoprotein]
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44180CC BY 4.0Reference data
CHEBI:88166+oxidized [electron-transfer flavoprotein]+hydron2-methylcrotonoyl-CoA+reduced [electron-transfer flavoprotein]
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48256CC BY 4.0Reference data