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Proteins/UNIPROT:Q8IY17
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids. Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides..
Function from UniProtKB (Q8IY17), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
7 rows
38 statements
38 statements · 5 reference databases · Subject: PNPLA6 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
11 reactions
1-O-acyl-sn-glycero-3-phosphocholine(1+)+waterproton+sn-glycerol 3-phosphocholine+fatty acid
Catalysed by LYPLA2 or PNPLA6 or PLA2G15 or PLA2G4A or LYPLA1 or PNPLA7 or PNPLA8 or PLB1 or ASPG or CLCF1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.5cytosol
2 names
Resolves to: PNPLA6
MAM00511c+waterproton+MAM02913c+fatty acid
Catalysed by LYPLA2 or PNPLA6 or PLA2G15 or PLA2G4A or LYPLA1 or PNPLA7 or PNPLA8 or PLB1 or ASPG or CLCF1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.5cytosol
Human-GEM MAR00645CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G6 or PLA2G4B or LIPC or PLA2G4A or PLB1 or PNPLA7 or ASPG or PNPLA6 or PLA2G15 or PNPLA8 or PLA2G4C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15177CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+waterglycerol+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by FAAH or CES2 or ABHD16A or EPHX1 or ABHD2 or CES1 or LIPE or PNPLA6 or ABHD12 or MGLL or ABHD6
Reaction pageLeft to rightBalanced
Rhea RHEA:26132CC BY 4.0Reference data
1-(9Z-octadecenoyl)-glycerol+waterglycerol+(9Z)-octadecenoate+hydron
Catalysed by DDHD2 or ABHD16A or PNLIPRP2 or LIPE or PLB1 or PNPLA6 or ABHD12 or MGLL or ABHD6 or ABHD16B
Reaction pageLeft to rightBalanced
Rhea RHEA:38487CC BY 4.0Reference data
2-(9Z-octadecenoyl)-glycerol+waterglycerol+(9Z)-octadecenoate+hydron
Catalysed by ABHD16A or LIPE or PLB1 or PNPLA6 or ABHD12 or MGLL or ABHD6
Reaction pageLeft to rightBalanced
Rhea RHEA:38491CC BY 4.0Reference data
1-hexadecanoylglycerol+waterglycerol+hexadecanoate+hydron
Catalysed by PNPLA6 or ABHD12 or MGLL
Reaction pageLeft to rightBalanced
Rhea RHEA:39959CC BY 4.0Reference data
2-hexadecanoylglycerol+waterglycerol+hexadecanoate+hydron
Catalysed by ABHD16A or PNPLA6 or ABHD12 or MGLL or ABHD6
Reaction pageLeft to rightBalanced
Rhea RHEA:39963CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G6 or LYPLA1 or LYPLA2 or PLA2G4B or LIPC or CEL or PLA2G4A or PLA2G4E or PLA2G4F or PLB1 or PNPLA7 or GDPD3 and 5 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40435CC BY 4.0Reference data
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+(9Z)-octadecenoate+hydron
Catalysed by PNPLA7 or ASPG or PNPLA6
Reaction pageLeft to rightBalanced
Rhea RHEA:40807CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphate+watersn-glycerol 3-phosphate+hexadecanoate+hydron
Catalysed by LYPLA2 or PNPLA7 or PNPLA6
Reaction pageLeft to rightBalanced
Rhea RHEA:49092CC BY 4.0Reference data