Pathway
Fluoropyrimidine activity
The main mechanism of 5-FU activation is conversion to fluorodeoxyuridine monophosphate (FdUMP), which inhibits the enzyme thymidylate synthase (TYMS). TYMS is an important part of the folate-homoc...
WP:1601
What the reference databases state
Statements
33 statements
33 statements · 1 reference database · Subject: Fluoropyrimidine activity · Sources: WikiPathways
- ABCC3 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- ABCC4 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- ABCC5 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- ABCG2 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- CDA participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- CES1 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- CES2 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- CYP2A6 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- DHFR participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- DPYD participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- DPYS participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- ERCC2 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
Show the remaining 21
- FPGS participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- GGH participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- MTHFR participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- PPAT participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- RRM1 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- RRM2 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- SLC22A7 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- SLC29A1 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- SMUG1 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- TDG participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- TK1 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- TP53 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- TYMP participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- TYMS participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- UCK1 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- UCK2 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- UMPS participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- UPB1 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- UPP1 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- UPP2 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only
- XRCC3 participates in Fluoropyrimidine activityProteinWikiPathways WP1601Inferred only