Pathway
Irinotecan pathway
This pathway shows the biotransformation of the chemotherapy prodrug irinotecan to form the active metabolite SN-38, an inhibitor of DNA topoisomerase I. SN-38 is primarily metabolized to the inact...
WP:229
What the reference databases state
Statements
12 statements
12 statements · 1 reference database · Subject: Irinotecan pathway · Sources: WikiPathways
- ABCC1 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- ABCC2 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- ABCG2 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- BCHE participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- CES1 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- CES2 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- CYP3A4 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- CYP3A5 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- SLCO1B1 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- UGT1A1 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- UGT1A10 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only
- UGT1A9 participates in Irinotecan pathwayProteinWikiPathways WP229Inferred only