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Proteins/UNIPROT:O15033
E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro. Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome..
Function from UniProtKB (O15033), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
52 statements
52 statements · 3 reference databases · Subject: AREL1 · Sources: gene ontology, Hetionet, Reactome
2 names
Resolves to: AREL1