Compound
benzoic acid
A fungistatic compound that is widely used as a food preservative. It is conjugated to glycine in the liver and excreted as hippuric acid.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C7H6O2
- Mass
- 122.123 g/mol
- Charge
- 0
- InChIKey
- WPYMKLBDIGXBTP-UHFFFAOYSA-N
- SMILES
- O=C(O)c1ccccc1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
14 statements
14 statements · 3 reference databases · Subject: benzoic acid · Sources: ChEBI, Human-GEM, Rhea
- benzaldehyde is converted to benzoic acidCompoundRhea RHEA:68868Inferred only
- benzoic acid is converted to benzaldehydeCompoundRhea RHEA:58960Inferred only
- benzoic acid is converted to benzaldehydeCompoundRhea RHEA:68868Inferred only
- benzaldehyde is converted to benzoic acidCompoundRhea RHEA:21660Inferred only
- benzaldehyde is converted to benzoic acidCompoundRhea RHEA:58960Inferred only
- benzaldehyde is converted to benzoic acidCompoundHuman-GEM MAR20038Inferred only
- benzaldehyde is converted to benzoic acidCompoundHuman-GEM MAR20039Inferred only
- benzaldehyde is converted to benzoic acidCompoundRhea RHEA:11840Inferred only
- benzoic acid is converted to benzoyl-CoACompoundRhea RHEA:10132Inferred only
- sodium benzoate is converted to benzoic acidCompoundChEBI CHEBI:113455Inferred only
- benzoic acid is metabolised by CES2ProteinRhea RHEA:27506Inferred only
- benzoic acid is a substrate of ACSM1ProteinRhea RHEA:10132Inferred only
Show the remaining 2
- benzoic acid is a substrate of ACSM2AProteinRhea RHEA:10132Inferred only
- benzoic acid is a substrate of ACSM2BProteinRhea RHEA:10132Inferred only
Reactions
26 reactions
Reaction pageReversibleBalancedEC 3.5.1.6extracellular space, cytosol
Human-GEM MAR00099CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR00100CC BY 4.0Reference data
cocaine+waterbenzoic acid+ecgonine methyl ester+proton
Catalysed by CES5A or CES3 or CES2 or CES1
Reaction pageLeft to rightBalancedEC 3.1.1.1, 3.1.1.84, 3.1.1.56cytosol
Human-GEM MAR08643CC BY 4.0Reference data
cocaine+waterbenzoic acid+ecgonine methyl ester+proton
Catalysed by CES2
Reaction pageLeft to rightBalancedEC 3.1.1.84endoplasmic reticulum
Human-GEM MAR08645CC BY 4.0Reference data
ATP+benzoic acid+CHEBI:1146900AMP+diphosphate(3-)+MAM03485m
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR10457CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10475CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR11297CC BY 4.0Reference data
water+NADP(3-)+benzaldehydebenzoic acid+2proton+NADPH(4-)
Catalysed by ALDH3B1
Reaction pageLeft to rightBalancedEC 1.2.1.7cytosol
Human-GEM MAR20038CC BY 4.0Reference data
water+NAD(+)+benzaldehydebenzoic acid+2proton+NADH(2-)
Catalysed by ALDH3B1
Reaction pageLeft to rightBalancedEC 1.2.1.28cytosol
Human-GEM MAR20039CC BY 4.0Reference data
benzoic acid+ATP(4-)+coenzyme A(4-)benzoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSM1 or ACSM2A or ACSM2B
Reaction pageLeft to rightBalanced
Rhea RHEA:10132CC BY 4.0Reference data
N-benzoylglycine+waterbenzoic acid+glycine
Reaction pageDirection not assertedBalanced
Rhea RHEA:10424CC BY 4.0Reference data
benzaldehyde+NAD(1-)+waterbenzoic acid+NADH(2-)+2hydron
Catalysed by ALDH1A1 or ALDH1B1 or ALDH3B1
Reaction pageLeft to rightBalanced
Rhea RHEA:11840CC BY 4.0Reference data
Papers screened
50 papers
- Compound
- benzoic acid
- Screened
- 50
- Admitted
- 0
- Discarded
- 5
- Not read
- 45
Discarded: the wrong intervention3 papers
- NCT00597909intervention×1 — no declared intervention names benzoic acid2026-09-29
- NCT04966507intervention×1 — no declared intervention names benzoic acid2026-09-29
- NCT02111200intervention×1 — no declared intervention names benzoic acid2026-09-29
Discarded: another reason, stated per paper2 papers
- NCT03180528design×1 — allocation NA -- not randomised2026-09-29
- NCT03875859design×1 — allocation NA -- not randomised2026-09-29
Not read yet45 papers
- PMID:79129602026-10-24
- PMID:247544942026-10-08
- PMID:17061042026-10-08
- PMID:18631042026-10-08
- PMID:19311562026-10-08
- PMID:108098572026-09-29
- PMID:151714942026-09-29
- PMID:174395672026-09-29
- PMID:18497602026-09-29
- PMID:237743062026-09-29
- PMID:314949912026-09-29
- PMID:324275042026-09-29
and 33 more.
Other names
8 names
Resolves to: benzoic acid
- Also called
- Aromatic carboxylic acidBenzenecarboxylic acidBenzeneformic acidBenzenemethanoic acidDracylic acidE210Phenylcarboxylic acidPhenylformic acid