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Proteins/UNIPROT:P22760
Catalyzes the hydrolysis of ester and amide bonds and is largely involved in prodrugs activation, xenobiotic detoxification or toxicity, and, in some contexts, lipid and indole metabolism. Prefers compounds with relatively small acyl groups, especially compounds with acetyl group. Participates in the hydrolysis of clinical drugs including acetyl esters compounds such as eslicarbazepine, abiraterone and rifamycins (rifampicin, rifabutin, and rifapentine) and N-acetylarylamine compounds such as flutamide, N-monoacetyldapsone, and phenacetin. Participates in the hydrolysis of carcinogen such as 2-acetylaminofluorene (AAF) and propanil. In addition, plays a role in lipid metabolism by hydrolyzing newly synthesized diacylglycerol, so limiting triacylglycerol synthesis for cytoplasmic storage droplet formation and for VLDL assembly. Can also catalyzes the deacetylation of cholesterol acetate. Moreover can play a role in metabolism of pineal indoles by catalyzing the deacetylation of N-acetylarylalkylamine compounds including N-acetylserotonin (NAS), melatonin and N-acetyltryptamine, NAS conversion being the most efficient reaction..
Function from UniProtKB (P22760), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
35 statements
35 statements · 6 reference databases · Subject: AADAC · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea
11 reactions
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+MAM01807e
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3extracellular space
5 names
Resolves to: AADAC
Human-GEM MAR00003CC BY 4.0Reference data
water+a triacylglycerola 1,2-diacyl-sn-glycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00665CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00667CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00668CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00669CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00670CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00671CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00672CC BY 4.0Reference data
water+an all-trans-retinyl esterproton+all-trans-retinol+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or RBP4 or CES5A or DAGLB or LIPC or CEL or CES3 and 8 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.1, 3.1.1.3cytosol
Human-GEM MAR06636CC BY 4.0Reference data
ecgonine methyl ester+waterCHEBI:708641+proton+methanol
Catalysed by AADAC
Reaction pageLeft to rightBalancedEC 3.1.1.3endoplasmic reticulum
Human-GEM MAR08648CC BY 4.0Reference data
a triacylglycerol+watera diacylglycerol+a fatty acid+hydron
Catalysed by DDHD2 or LPL or LIPF or ABHD2 or LIPC or PNLIP or CEL or AADAC or PNPLA4 or PNLIPRP2 or LIPE or PNLIPRP3 and 7 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12044CC BY 4.0Reference data