Pathway
Aspirin ADME
In water aspirin (acetylsalicylic acid, ASA) dissolves, dissociating into the acetylsalicylate ion (ASA-). ASA- is an anti-clotting agent and nonsteroidal anti-inflammatory drug (NSAID); the therapeutic effects are mediated through its interaction with PTGS enzymes. On a molar basis ASA- (a) is more potent as an analgesic/anti-inflammatory agent, (b) has greater gastric ulcerogenic activity, and (c) is much more effective as an inhibitor of prostaglandin biosynthesis and platelet aggregation than salicylate (ST).
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Acetylsalicylic acid is only slightly soluble in conditions being found in the stomach mucosa, mostly because of unavailability of sufficient amount of solvent. The absorption, as well as the absorbing area, increases in the small intestine. Further increased absorption is achieved by dissolving tablets before ingestion or usage of ASA salts. Practically 100% of therapeutic aspirin doses are taken up, mostly by intestinal mucosal cells.
Only a few percent of ASA- remain unchanged, the rest is hydrolyzed to salicylate (ST). The major route of ST catabolism is conjugation with glycine to form salicyluric acid. This accounts for 20–65% of the products. Conjugation to glucuronides (ester and ether) removes up to 42% of ST. Finally, a minor part also gets hydroxylated by cytochromes.
What the reference databases state
Statements
42 statements
42 statements · 1 reference database · Subject: Aspirin ADME · Sources: Reactome
- ABCC2 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- ABCC3 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- ACSM2A participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- ACSM2B participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- ACSM4 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- ACSM5 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- ALB participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- BCHE participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- BSG participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- CES1 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- CES2 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- CYP2C19 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
Show the remaining 30
- CYP2C8 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- CYP2C9 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- CYP2D6 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- CYP2E1 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- CYP3A4 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- GLYAT participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- GLYATL1 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- GLYATL2 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- GLYATL3 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- SLC16A1 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT1A1 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT1A3 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT1A4 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT1A5 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT1A6 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT1A7 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT1A8 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT1A9 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2A1 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2A2 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2A3 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2B10 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2B11 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2B15 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2B17 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2B28 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2B4 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT2B7 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT3A1 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only
- UGT3A2 participates in Aspirin ADMEProteinReactome R-HSA-9749641Inferred only