Pathway
Drug ADME
Pharmacokinetics (PK) is a branch of pharmacology dedicated to determining the chemical fate of substances in living organisms, from administration to elimination from the body. PK can be described as how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how a drug affects the organism. Both PK and PD are described for each drug annotated in the Drug Absorption, Distribution, Metabolism and Excretion (ADME) pathways. For example, although paracetamol ADME (PK) is described in this section, the pharmacological inhibition (PD) of its targets (PTGS1 and PTGS2) is described in the relevant pathway where these enzymes perform their physiological duties. A connection is made between the two pathways to link PK and PD annotations.
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The disposition of a pharmaceutical compound within an organism can be described by four main stages; absorption, distribution, metabolism, and excretion, abbreviated to ADME. Sometimes, separate steps can be tacked on to ADME depending on what is being described. For example, where a drug is released from a pharmaceutical formulation, liberation (L) is added to ADME (LADME) or where the toxicity of a compound is described, T is added (ADMET).
ADME of various drugs is annotated in this section.
REACT:R-HSA-9748784Reactome
What the reference databases state
Statements
108 statements
108 statements · 1 reference database · Subject: Drug ADME · Sources: Reactome
- ABCB1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ABCC1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ABCC2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ABCC3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ABCC4 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ABCC5 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ABCG2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ACSM2A participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ACSM2B participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ACSM4 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ACSM5 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ACY1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
Show the remaining 96
- ADA participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ADH1A participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ADK participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- AKR1C1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ALB participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- BCHE participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- BSG participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CES1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CES2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CNDP2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CYP2C19 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CYP2C8 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CYP2C9 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CYP2D6 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CYP2E1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- CYP3A4 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GGT1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GGT3P participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GGT5 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GGT6 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GGT7 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GLYAT participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GLYATL1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GLYATL2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GLYATL3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GMPS participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GSTA1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GSTA2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GSTM1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GSTP1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GSTT1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- GUK1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- HPRT1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- HSD11B1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- HSD11B2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- IMPDH1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- IMPDH2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- ITPA participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- MAPDA participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- NAT1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- NAT2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- NME1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- NME2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- NT5C2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- NUDT15 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- PCK1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- PNP participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- PON1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- PON3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- RAC1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SERPINA6 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC16A1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC22A1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC22A2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC22A3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC22A8 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC28A2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC28A3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC29A1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC29A2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLC29A3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLCO1A2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLCO1B1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SLCO1B3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SULT1A1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SULT1A3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SULT1A4 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SULT1C4 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SULT1E1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- SULT2A1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- TPMT participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A10 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A4 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A5 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A6 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A7 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A8 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT1A9 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2A1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2A2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2A3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2B10 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2B11 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2B15 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2B17 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2B28 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2B4 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT2B7 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT3A1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- UGT3A2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- VAV1 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- VAV2 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- VAV3 participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only
- XDH participates in Drug ADMEProteinReactome R-HSA-9748784Inferred only