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Proteins/UNIPROT:Q6UWW8
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Function from UniProtKB (Q6UWW8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
16 statements
16 statements · 5 reference databases · Subject: CES3 · Sources: Bgee, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
water+an all-trans-retinyl esterproton+all-trans-retinol+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or RBP4 or CES5A or DAGLB or LIPC or CEL or CES3 and 8 more alternatives
1 name
Resolves to: CES3
Human-GEM MAR06636CC BY 4.0Reference data
cocaine+waterbenzoic acid+ecgonine methyl ester+proton
Catalysed by CES5A or CES3 or CES2 or CES1
Reaction pageLeft to rightBalancedEC 3.1.1.1, 3.1.1.84, 3.1.1.56cytosol
Human-GEM MAR08643CC BY 4.0Reference data
a carboxylic ester+wateran alcohol+a carboxylate+hydron
Catalysed by CES2 or CES1 or CES5A or CES3 or OVCA2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21164CC BY 4.0Reference data