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Proteins/UNIPROT:Q9Y6T7
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity)..
[Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity..
Function from UniProtKB (Q9Y6T7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
32 statements
32 statements · 4 reference databases · Subject: DGKB · Sources: Hetionet, Human-GEM, Reactome, Rhea
6 reactions
6 names
Resolves to: DGKB
a 1,2-diacyl-sn-glycerol+ATP(4-)a 1,2-diacyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10272CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+ATP(4-)1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40323CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+ATP(4-)1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40327CC BY 4.0Reference data
1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol+ATP(4-)1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKG or DGKE or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40339CC BY 4.0Reference data
1,2-didecanoyl-sn-glycerol+ATP(4-)1,2-didecanoyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKG or DGKZ or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:43428CC BY 4.0Reference data