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Proteins/UNIPROT:Q92611
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2..
Function from UniProtKB (Q92611), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
421 statements
421 statements · 4 reference databases · Subject: EDEM1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
3 names
Resolves to: EDEM1