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Proteins/UNIPROT:O43684
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1..
Function from UniProtKB (O43684), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
122 statements
122 statements · 3 reference databases · Subject: BUB3 · Sources: Hetionet, Reactome, WikiPathways
1 name
Resolves to: BUB3