an N(2)-acyl-L-glutamine

Three steps

• (9Z)-octadecenoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by GLYATL1B, GLYATL1, SCD, SCD5cytosol

• phytanoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. phytanate-CoA ligase

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 2 moremitochondrial matrix, cytosolOne of 5 routes

• D-alanineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, PIPOXextracellular space, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, SHMT1 and 1 moreextracellular space, cytosol

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, ASLextracellular space, cytosolOne of 6 routes

• 4-guanidinobutanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, GATMextracellular space, cytosol

• L-dopaReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase

  Catalysed by GLYATL1B, GLYATL1, GFPT2, GFPT1 and 1 morecytosolOne of 3 routes

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• a long-chain fatty acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
  3. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)

  Catalysed by GLYATL1B, GLYATL1, GNPAT, AGPS

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A13, ADSS2 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, GATMextracellular space, cytosol

• L-histidineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• ethanolamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase
  3. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase

  Catalysed by GLYATL1B, GLYATL1, LPCAT4, LPCAT3 and 4 morecytosolOne of 4 routes

• beta-D-fructose 6-phosphateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)

  Catalysed by GLYATL1B, GLYATL1, GFPT2, GFPT1 and 2 morecytosol

• D-ornithineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 3 moreextracellular space, cytosolOne of 3 routes

• guanidinoacetateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GATMextracellular space, cytosolOne of 5 routes

• sphing-4-enineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 6 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• D-threonineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)

  Catalysed by GLYATL1B, GLYATL1, LCLAT1, MBOAT7 and 1 more

• sphinganineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. sphingosine N-acyltransferase (sphinganine)
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by GLYATL1B, GLYATL1, CERS1, CERS6 and 7 morecytosol

• spermidineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 4 moremitochondrial matrix, cytosolOne of 3 routes

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by GLYATL1B, GLYATL1, LPGAT1One of 12 routes

• CDP-ethanolamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)

  Catalysed by GLYATL1B, GLYATL1, LPCAT4, LPCAT3 and 4 morecytosol

• L-dopaquinoneReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, TYRextracellular space, cytosol

• glutathioneReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GSSextracellular space, cytosol

• L-saccharopineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, AASSextracellular space, cytosol, mitochondrial matrix

• L-kynurenineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, KYNUcytosolOne of 5 routes

• beta-alanineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• leukotriene C4Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. leukotriene C4 hydrolysis

  Catalysed by GLYATL1B, GLYATL1, SLC7A5extracellular space, cytosol

• taurocyamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, GATMextracellular space, cytosol

• L-glutamate 5-semialdehydeReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, OATextracellular space, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by GLYATL1B, GLYATL1, SLC7A13, AGAinner side of the membrane, outer side of the membrane

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)

  Catalysed by GLYATL1B, GLYATL1, LCLAT1, MBOAT7 and 7 more

• 3-hydroxy-L-kynurenineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, KYNUcytosol

• L,L-cystathionineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 3 moremitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by GLYATL1B, GLYATL1, LPGAT1, PLA2G10 and 29 moreOne of 14 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 3 moreextracellular space, cytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)

  Catalysed by GLYATL1B, GLYATL1, LPGAT1, OSBPL3inner side of the membrane, outer side of the membraneOne of 5 routes

• 6-amino-2-oxohexanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by GLYATL1B, GLYATL1, SLC7A6extracellular space, cytosol, peroxisome

• phosphoethanolamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = phosphoethanolamine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by GLYATL1B, GLYATL1, LPCAT4, LPCAT3 and 3 more

• L-homocysteineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, BHMT2extracellular space, cytosol

• S-methyl-L-methionineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, BHMT2extracellular space, cytosol

• 3-oxosphinganineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

  Catalysed by GLYATL1B, GLYATL1, SPTLC1, SPTLC2 and 1 morecytosol

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by GLYATL1B, GLYATL1, GNPATcytosol, peroxisome

• L-tyrosineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, AADATextracellular space, cytosolOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GLYATL1B, GLYATL1, KYAT1, AGXT2cytosolOne of 7 routes

• a CDP-1,2-diacyl-sn-glycerolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
  3. a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate

  Catalysed by GLYATL1B, GLYATL1, AGPAT2, GPAT3 and 14 moreOne of 3 routes