3-oxooctadecanoyl-CoA

Three steps

• octadecanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Fas180

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 6 routes

• octanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. Octanoyl-CoA hydrolase

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 9 moreperoxisome, cytosolOne of 7 routes

• elaidic acidReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 7 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-peroxy-docosahexaenoate to DHA conversion

  Catalysed by ACAA1, MYO5B, DGAT1, LRAT and 3 moreperoxisome, cytosol

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by SCP2, HADHB, LPCAT3, LPCAT1 and 1 moreOne of 2 routes

• CHEBI:28701Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosolOne of 7 routes

• phosphocholineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by SCP2, HADHB, PRDX6, LPCAT3 and 2 more

• tetradecanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
  3. Myristoyl-CoA hydrolase

  Catalysed by ACAA1, MYO5B, HADHA, ACADVL and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
  3. 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)

  Catalysed by SCP2, HADHB, DGAT1, AWAT2 and 2 moreOne of 7 routes

• an N-acylsphinganineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by ACAA1, MYO5B, CERS1, CERS6 and 4 moreperoxisome, cytosol

• octadecan-1-olReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA

  Catalysed by ACAA1, MYO5B, FAR1, FAR2peroxisome, cytosol

• (9Z)-hexadecenoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. Palmitoleoyl-CoA hydrolase

  Catalysed by ACAA1, MYO5B, SCD, ACOT7 and 4 moreperoxisome, cytosolOne of 2 routes

• fatty acidReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 4 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 2 moreperoxisome, cytosol

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (9Z-octadecenoate) + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by SCP2, HADHB, LPGAT1, LCAT

• a 1,3-diacylglycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT1peroxisome, cytosol

• a 1,2-diacylglycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT3 and 3 moreperoxisome, cytosolOne of 2 routes

• taurineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 2 routes

• 16-hydroxyhexadecanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosol, endoplasmic reticulumOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 1 moreperoxisome, cytosol

• glycineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 11 routes

• (R)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• 3-oxohexadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
  3. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA

  Catalysed by ACAA1, MYO5B, HADHA, ACADVL and 3 moreperoxisome, mitochondrial matrix

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 8 routes

• butanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 9 moreperoxisome, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 12 routes

• glutaryl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Production of Glutaryl Carnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 13 routes

• itaconyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 14 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by ACAA1, MYO5B, SCD, SCD5peroxisome, cytosol

• phytanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. phytanate-CoA ligase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 5 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate

  Catalysed by ACAA1, MYO5B, GNPAT, AGPSperoxisomeOne of 2 routes

• sn-glycerol 3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 5 moreperoxisome, cytosol

• ethanolamineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine

  Catalysed by SCP2, HADHB, LPGAT1, PTDSS2

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome, cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, GLYATL3, GLYAT and 1 moreperoxisome, cytosol

• sphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 7 moreperoxisome, cytosol, Golgi apparatusOne of 4 routes

• sphinganineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
  3. sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)

  Catalysed by ACAA1, MYO5B, SPTLC1, SPTLC2 and 2 moreperoxisome, cytosolOne of 2 routes

• spermidineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 3 routes

• L-methionineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ACAA1, MYO5B, LCLAT1, MBOAT7peroxisome, cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 2 moreperoxisome, cytosol

• L-alanineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol, mitochondrial matrix