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Proteins/UNIPROT:Q9BVG9
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine to form phosphatidylserine. Lacks phosphatidylcholine-dependent base-exchange activity. Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity)..
Function from UniProtKB (Q9BVG9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 6 reference databases · Subject: PTDSS2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
10 reactions
phosphatidylethanolamine+L-seryl residueethanolamine+phosphatidyl-L-serine
Catalysed by PTDSS2
Reaction pageLeft to rightBalance undeterminableEC 2.7.8.29cytosol
Human-GEM MAR00622CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphoethanolamine+L-seryl residuea 1,2-diacyl-sn-glycero-3-phospho-L-serine+ethanolamine
4 names
Resolves to: PTDSS2
Rhea RHEA:27606CC BY 4.0Reference data
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+L-seryl residue1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine+ethanolamine
Catalysed by PTDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:40795CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+L-seryl residue1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine+ethanolamine
Catalysed by PTDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:41484CC BY 4.0Reference data
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine+L-seryl residue1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine+ethanolamine
Catalysed by PTDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:41488CC BY 4.0Reference data
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine+L-seryl residue1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine+ethanolamine
Catalysed by PTDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:41492CC BY 4.0Reference data
1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine+L-seryl residue1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine+ethanolamine
Catalysed by PTDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:41496CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine+L-seryl residue1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine+ethanolamine
Catalysed by PTDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:41500CC BY 4.0Reference data
1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+L-seryl residue1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine+ethanolamine
Catalysed by PTDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:41600CC BY 4.0Reference data
1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+L-seryl residue1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine+ethanolamine
Catalysed by PTDSS2
Reaction pageLeft to rightBalanced
Rhea RHEA:41604CC BY 4.0Reference data