an acyl-CoA

Two steps

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Docosanoyl-CoA hydrolase

  Catalysed by BAAT, ACOT6cytosolOne of 4 routes

• octadecanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Stearoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 4 routes

• alpha-linolenic acidReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Linolenoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, ACOT1cytosol

• CHEBI:27540Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 6 moremitochondrial matrix, cytosolOne of 6 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by BAAT, ACOT6cytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. acyl-CoA pool formation and breakdown
  2. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by FAR2cytosol

• CHEBI:28701Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, peroxisomeOne of 7 routes

• a fatty acidReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 20 morecytosolOne of 26 routes

• phosphocholineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by LPGAT1, SMPD1

• (9Z,12Z)-octadecadienoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)

  Catalysed by ACOT8, ACOT2, THEM5, ACOT4cytosol

• tetradecanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Myristoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Oleoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 6 morecytosolOne of 3 routes

• docosan-1-olReach from here →
  1. acyl-CoA pool formation and breakdown
  2. docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA

  Catalysed by FAR2cytosol

• hexacosanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Hexacosanoyl-CoA hydrolase

  Catalysed by BAAT, ACOT6cytosolOne of 2 routes

• tetracosanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Tetracosenoyl-CoA hydrolase

  Catalysed by BAAT, THEM4cytosolOne of 4 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. sphingosine N-acyltransferase (sphinganine)
  2. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosolOne of 3 routes

• octadecan-1-olReach from here →
  1. acyl-CoA pool formation and breakdown
  2. octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA

  Catalysed by FAR1, FAR2cytosol

• eicosanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Eicosanoyl-CoA hydrolase

  Catalysed by BAAT, ACOT6, ACOT1cytosolOne of 4 routes

• (9Z)-hexadecenoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Palmitoleoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• (15Z)-tetracosenoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (15Z)-tetracosenoyl-CoA hydrolase

  Catalysed by BAAT, ACOT6cytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Arachidonyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• (11Z)-eicosenoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (11Z)-eicosenoyl-CoA hydrolase

  Catalysed by BAAT, ACOT6, ACOT1cytosol

• fatty acidReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. triacylglycerol acylhydrolase

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 2 morecytosol, extracellular spaceOne of 24 routes

• a 1-acylglycerolReach from here →
  1. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
  2. a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)

  Catalysed by MOGAT2, MOGAT3, LPGAT1, TMEM68 and 2 moreOne of 2 routes

• a sterol esterReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by LPGAT1, LCAT

• cholesteryl hexadecanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 5 routes

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 6 routes

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 5 routes

• taurineReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 moremitochondrial matrix, cytosolOne of 2 routes

• an N-acylsphing-4-enineReach from here →
  1. sphingosine N-acyltransferase (sphinganine)
  2. delta 4-desaturase, sphingolipid (dihydroceramide pool)

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosolOne of 6 routes

• N-tetracosanoylsphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)

  Catalysed by CERS3, CERS2, CERS4cytosol

• N-hexacosanoylsphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)

  Catalysed by CERS3, CERS2, CERS4cytosol

• a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)

  Catalysed by LCLAT1, MBOAT7, PIGA

• glycineReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 10 routes

• a (3S)-3-hydroxyacyl-CoAReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 3 more

• (R)-methylmalonyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 moremitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 moremitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrixOne of 8 routes

• 3-oxohexadecanoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA

  Catalysed by ELOVL6, ELOVL3cytosol

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 2 moremitochondrial matrix, peroxisomeOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by FADS1cytosol

• butanoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 6 moremitochondrial matrix, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Production of Glutaryl Carnitine

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, cytosolOne of 2 routes

• hexadecanoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by SCD, SCD5cytosol

• itaconyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 2 routes

• octanoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 moremitochondrial matrixOne of 30 routes