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Proteins/UNIPROT:Q9HA82
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor..
Function from UniProtKB (Q9HA82), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
109 statements
109 statements · 6 reference databases · Subject: CERS4 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
11 reactions
CHEBI:16566+an acyl-CoACHEBI:1146900+an N-acylsphinganine+proton
Catalysed by CERS4 or CERS5 or CERS2 or CERS3 or CERS6 or CERS1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00750CC BY 4.0Reference data
3 names
Resolves to: CERS4
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00758CC BY 4.0Reference data
sphing-4-enine+a fatty acyl-CoAan N-acylsphing-4-enine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS3 or CERS5 or CERS2 or CERS4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23768CC BY 4.0Reference data
hexacosanoyl-CoA+sphinganineN-hexacosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:33351CC BY 4.0Reference data
tetracosanoyl-CoA+sphinganineN-tetracosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:33591CC BY 4.0Reference data
a fatty acyl-CoA+sphinganinean N-acylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS5 or CERS4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:34735CC BY 4.0Reference data
docosanoyl-CoA+sphinganineN-docosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36535CC BY 4.0Reference data
sphinganine+octadecanoyl-CoAN-(octadecanoyl)-sphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS3 or CERS5 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36547CC BY 4.0Reference data
eicosanoyl-CoA+sphinganineN-eicosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36555CC BY 4.0Reference data
sphing-4-enine+octadecanoyl-CoAN-octadecanoylsphing-4-enine+coenzyme A(4-)+hydron
Catalysed by CERS1 or TLCD3B or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36691CC BY 4.0Reference data
hexadecasphinganine+octadecanoyl-CoAN-octadecanoylhexadecasphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:43044CC BY 4.0Reference data