an N-acyl-(4R)-4-hydroxysphinganine

1. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

Catalysed by SGMS2, SAMD8One of 2 routes

1. an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid

Catalysed by ACER3

1. Phytoceramide amidohydrolase

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol

1. Phytoceramide amidohydrolase

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosolOne of 2 routes

1. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

Catalysed by SGMS1, SGMS2

1. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

Catalysed by SGMS2, SAMD8

1. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

Catalysed by SGMS2, SAMD8, DGAT1, MOGAT2 and 3 morecytosol

1. an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid
2. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

Catalysed by ACER3, AOAH