an acyl-CoA

Two steps

• CHEBI:15380Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 2 moremitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Production of Tiglylcarnitine

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 2 moremitochondrial matrix, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 moremitochondrial matrix

• isovaleryl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 3 routes

• CHEBI:15519Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. propanoyl-CoA C-acyltransferase

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, peroxisomeOne of 2 routes

• phenylacetyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Phenylacetate:CoA ligase

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Propanoate:CoA ligase (AMP-forming)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, cytosolOne of 46 routes

• CHEBI:15650Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 32 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 moremitochondrial matrix, cytosol

• CHEBI:15746Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 2 moremitochondrial matrix, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Palmitoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• 1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  2. plasmenylethanolamine 2-acylhydrolase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 18 morecytosol

• cholesterolReach from here →
  1. an acyl-CoA + cholesterol = a cholesterol ester + CoA
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

  Catalysed by SOAT2, SOAT1, CES1, LIPN and 2 more

• hexadecan-1-olReach from here →
  1. acyl-CoA pool formation and breakdown
  2. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by FAR1, FAR2cytosol, peroxisome

• 11-cis-retinyl hexadecanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 1 morecytosol

• 11-cis-retinolReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 5 moremitochondrial matrix, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. ATP citrate lyase (citrate)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 moremitochondrial matrix, cytosol

• CHEBI:16566Reach from here →
  1. sphingosine N-acyltransferase (sphinganine)
  2. N-acylsphingosine amidohydrolase

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 7 morecytosol

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by NUDT19cytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by NUDT19cytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by NUDT19cytosol

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by CERS1cytosol

• myo-inositolReach from here →
  1. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  2. a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)

  Catalysed by LCLAT1, MBOAT7, CDIPT

• anilineReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 2 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 2 routes

• all-trans-retinolReach from here →
  1. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA
  2. carboxylesterase (retinyl-ester)

  Catalysed by DGAT1, PNPLA4, AWAT2, DGAT2 and 19 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Linoleoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol

• a 2-acylglycerolReach from here →
  1. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  2. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)

  Catalysed by MOGAT2, AWAT2, MOGAT1, DAGLB and 2 more

• a monoacylglycerolReach from here →
  1. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  2. 1,2-diacyl-sn-glycerol acylhydrolase

  Catalysed by MOGAT2, AWAT2, MOGAT1, LIPF and 14 moreextracellular spaceOne of 8 routes

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by CPT2, CPT1Acytosol, peroxisomeOne of 4 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. phosphatidylcholine 2-acylhydrolase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 18 morecytosol, endoplasmic reticulumOne of 8 routes

• L-cysteineReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 moremitochondrial matrix

• a sphingomyelinReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 2 morecytosol, Golgi apparatusOne of 5 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 2 routes

• glycerolReach from here →
  1. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
  2. a 1-acylglycerol + a 1,2-diacylglycerol = a triacylglycerol + glycerol

  Catalysed by MOGAT2, MOGAT3, LPGAT1, TMEM68 and 4 moreOne of 2 routes

• CHEBI:17927Reach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosol

• a diacylglycerolReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 20 morecytosolOne of 2 routes

• L-glutamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by GLYATL1B, GLYATL1

• dodecanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Lauroyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13cytosolOne of 2 routes

• phosphatidyl-L-serineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. phosphatidylserine synthase (PC-LD pool)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosolOne of 2 routes

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by ACOX1cytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPGAT1cytosol

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 2 routes

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by ELOVL7, ELOVL1, ELOVL4, ELOVL6 and 3 morecytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 5 routes

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by ACADL, ACADVL, ACAD9cytosolOne of 2 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrixOne of 2 routes