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Proteins/UNIPROT:Q9GZR5
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development..
Function from UniProtKB (Q9GZR5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
71 statements
71 statements · 7 reference databases · Subject: ELOVL4 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
61 reactions
(6Z,9Z,12Z)-octadecatrienoyl-CoA+5proton+malonyl-CoA+4NADPH(4-)+dioxygencarbon dioxide+CHEBI:1146900+(8Z,11Z,14Z)-eicosatrienoyl-CoA+3water+4NADP(3-)
Catalysed by ELOVL5 or ELOVL4 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
6 names
Resolves to: ELOVL4
Human-GEM MAR00743CC BY 4.0Reference data
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA+5proton+malonyl-CoA+4NADPH(4-)+dioxygen(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA+carbon dioxide+CHEBI:1146900+3water+4NADP(3-)
Catalysed by ELOVL5 or ELOVL4 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
Human-GEM MAR00745CC BY 4.0Reference data
arachidonoyl-CoA+5proton+malonyl-CoA+4NADPH(4-)+dioxygenCHEBI:63544+carbon dioxide+CHEBI:1146900+3water+4NADP(3-)
Catalysed by ELOVL5 or ELOVL4 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
Human-GEM MAR00747CC BY 4.0Reference data
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA+5proton+malonyl-CoA+4NADPH(4-)+dioxygen(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA+carbon dioxide+CHEBI:1146900+3water+4NADP(3-)
Catalysed by ELOVL5 or ELOVL4 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
Human-GEM MAR00749CC BY 4.0Reference data
proton+malonyl-CoA+palmitoyl-CoA3-oxooctadecanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02190CC BY 4.0Reference data
proton+malonyl-CoA+octadecanoyl-CoA3-oxoeicosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02201CC BY 4.0Reference data
eicosanoyl-CoA+proton+malonyl-CoA3-oxodocosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02205CC BY 4.0Reference data
docosanoyl-CoA+proton+malonyl-CoA3-oxotetracosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02211CC BY 4.0Reference data
proton+malonyl-CoA+tetracosanoyl-CoA3-oxohexacosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02215CC BY 4.0Reference data
proton+heptadecanoyl-CoA+malonyl-CoAMAM00887c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02259CC BY 4.0Reference data
proton+malonyl-CoA+nonadecanoyl-CoAMAM00873c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02263CC BY 4.0Reference data
proton+MAM02052c+malonyl-CoAMAM00907c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02267CC BY 4.0Reference data