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Proteins/UNIPROT:Q9BW60
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs..
Function from UniProtKB (Q9BW60), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
173 statements
173 statements · 7 reference databases · Subject: ELOVL1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
94 reactions
proton+malonyl-CoA+palmitoyl-CoA3-oxooctadecanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02190CC BY 4.0Reference data
7 names
Resolves to: ELOVL1
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02201CC BY 4.0Reference data
eicosanoyl-CoA+proton+malonyl-CoA3-oxodocosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02205CC BY 4.0Reference data
docosanoyl-CoA+proton+malonyl-CoA3-oxotetracosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02211CC BY 4.0Reference data
proton+malonyl-CoA+tetracosanoyl-CoA3-oxohexacosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02215CC BY 4.0Reference data
proton+heptadecanoyl-CoA+malonyl-CoAMAM00887c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02259CC BY 4.0Reference data
proton+malonyl-CoA+nonadecanoyl-CoAMAM00873c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02263CC BY 4.0Reference data
proton+MAM02052c+malonyl-CoAMAM00907c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02267CC BY 4.0Reference data
proton+malonyl-CoA+oleoyl-CoAMAM00840c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02305CC BY 4.0Reference data
(11Z)-eicosenoyl-CoA+proton+malonyl-CoAMAM00842c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02315CC BY 4.0Reference data
(13Z)-docosenoyl-CoA+proton+malonyl-CoAMAM00856c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02324CC BY 4.0Reference data
(15Z)-tetracosenoyl-CoA+proton+malonyl-CoA3-oxohexacosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02332CC BY 4.0Reference data