N-sulfo-D-glucosamine

Three steps

• ubiquinonesReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by SGSH, SLC25A10, SDHD, SDHB and 2 moremitochondrial matrix, cytosol

• L-valineReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• oxaloacetateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by SGSH, SLC25A10mitochondrial matrix, cytosolOne of 11 routes

• L-arginineReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, SLC6A14extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by SGSH, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosol

• pregnenoloneReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by SGSH, STSGolgi apparatus, cytosolOne of 4 routes

• 3-fumarylpyruvateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by SGSH, SLC25A10, FAHD1mitochondrial matrix, cytosol

• CHEBI:16857Reach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by SGSH, SLC26A6, SLC6A14extracellular space, cytosol

• ferrocytochrome cReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SGSH, SLC25A14, SLC25A30, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• N-acetyl-L-aspartateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SGSH, SLC25A14, SLC25A30, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• L-isoleucineReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, SLC6A14extracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by SGSH, SLC26A6, CLTRN, SLC6A20extracellular space, cytosolOne of 3 routes

• estroneReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SGSH, STScytosolOne of 3 routes

• propanoateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SGSH, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• enol-oxaloacetateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SGSH, SLC25A10, SDHB, SDHAmitochondrial matrix, cytosol

• L-cysteineReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, SLC6A14extracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronineReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by SGSH, STSGolgi apparatusOne of 3 routes

• glycine betaineReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, SLC6A12extracellular space, cytosolOne of 3 routes

• urateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by SGSH, SLC25A35, SLC25A34, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SGSH, SLC26A6, SLC6A14extracellular space, cytosolOne of 2 routes

• butanoateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SGSH, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, SLC6A14extracellular space, cytosol

• thiocyanateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SGSH, SLC25A14, SLC25A30, SLC26A1 and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SGSH, SLC25A10, FAHmitochondrial matrix, cytosol

• L-glutamineReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SGSH, SLC26A6, SLC6A14extracellular space, cytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, CLTRN, SLC6A20extracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SGSH, SLC26A6extracellular space, cytosolOne of 2 routes

• hydrogen cyanideReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SGSH, SLC25A14, SLC25A30, MPST and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SGSH, SLC25A35, SLC25A34, SLC22A6 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SGSH, SLC25A35, SLC25A34, SLC22A6 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:240943Reach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SGSH, SLC26A6, SLC6A5extracellular space, cytosolOne of 2 routes

• a quinolReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SGSH, SLC25A10, SDHB, SDHAmitochondrial matrix, cytosol

• hypochlorous acidReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SGSH, SLC26A6, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, SLC12A2, SLC12A1extracellular space, cytosolOne of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SGSH, STScytosolOne of 3 routes

• K(+)Reach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SGSH, SLC25A14, SLC25A30, SLC1A7 and 4 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SGSH, SLC25A14, SLC25A30, DARS1inner side of the membrane, outer side of the membrane, cytosol

• hydrogen sulfideReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SGSH, SLC25A14, SLC25A30, SLC26A1 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• formic acidReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SGSH, SLC26A6, SLC26A4extracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by SGSH, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 10 routes

• (indol-3-yl)acetateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SGSH, SLC25A35, SLC25A34, SLC22A6 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• isocitric acidReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SGSH, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 6 routes

• glutarateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by SGSH, STS, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 4 routes

• pentanoateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SGSH, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• cis-aconitic acidReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SGSH, SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 6 routes

• N-carbamoyl-L-aspartateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SGSH, SLC25A14, SLC25A30, CADinner side of the membrane, outer side of the membrane

• a phenolReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SGSH, ARSL, ARSF, ARSK and 3 more

• glyoxylateReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SGSH, SLC25A10, CLYBLmitochondrial matrix, cytosol

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SGSH, SLC25A35, SLC25A34, SLC22A6 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SGSH, SLC4A1, ALDH9A1extracellular space, cytosol