guanidinoacetate

Two steps

• CHEBI:18095Reach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20extracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. Transport of Guanidinoacetic Acid
  2. Transport of 3-Ureidopropionate

  No catalyst recordedextracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GATM, GARTcytosol

• ophthalmateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GATM, GSScytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GATM, AGXT2cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by GATM, SHMT1cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GATM, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. Transport of Guanidinoacetic Acid
  2. Peroxidase

  Catalysed by LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of chloride (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1extracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GATM, GLYATcytosolOne of 3 routes

• CHEBI:28666Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. LTD4 hydrolysis

  Catalysed by GATMcytosol

• Gly-tRNA(Gly)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GATM, GARS1cytosol

• glycocholateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GATM, BAATcytosol, peroxisomeOne of 3 routes

• formic acidReach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC26A4extracellular space, cytosolOne of 2 routes

• malonic acidReach from here →
  1. Transport of Guanidinoacetic Acid
  2. Malonate Transport, Antiport with Chloride

  No catalyst recordedextracellular space, cytosolOne of 2 routes

• L-lysineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by GATM, SLC7A9, SLC25A29, SLC7A6cytosol, inner side of the membrane, outer side of the membrane

• putrescineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by GATM, SLC3A2, SLC7A7cytosol, extracellular space

• 5-aminolevulinateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by GATM, ALAS1, ALAS2cytosol

• glycochenodeoxycholateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by GATM, BAATcytosol

• glycochenodeoxycholic acidReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GATM, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by GATM, AADATcytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by GATM, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by GATM, GCATcytosol, mitochondrial matrix

• L-ornithineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-Arginine amidinohydrolase

  Catalysed by GATM, ARG1cytosolOne of 19 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by GATM, GLDC, GCSHcytosol, mitochondrial matrix

• taurineReach from here →
  1. Transport of Guanidinoacetic Acid
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC6A6extracellular space, cytosolOne of 2 routes

• sarcosineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by GATM, PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by GATM, SHMT1, SHMT2cytosol

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by GATM, ASLcytosolOne of 2 routes

• 4-guanidinobutanoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by GATMcytosol

• 3-guanidinopropanoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by GATMcytosol

• L-histidineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)

  Catalysed by GATM, SLC7A6cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• an N-acylglycineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GATM, GLYATL3, GLYAT, GLYATL2cytosol

• L-methionineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and methionine (cytosol to extracellular)

  Catalysed by GATM, SLC7A6cytosol, extracellular spaceOne of 12 routes

• L-tryptophanReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and tryptophan (cytosol to extracellular)

  Catalysed by GATM, SLC7A6cytosol, extracellular spaceOne of 9 routes

• glutathioneReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by GATM, GSScytosol

• beta-alanineReach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC6A6, SLC6A14extracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of alanine and arginine (cytosol to extracellular)

  Catalysed by GATM, SLC7A6cytosol, extracellular spaceOne of 11 routes

• leukotriene C4Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. leukotriene C4 hydrolysis

  Catalysed by GATMcytosol

• L-asparagineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and asparagine (cytosol to extracellular)

  Catalysed by GATM, SLC7A6cytosol, extracellular spaceOne of 8 routes

• taurocyamineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by GATMcytosol

• N-phosphocreatineReach from here →
  1. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  2. creatine kinase (creatine)

  Catalysed by GAMT, CKM, CKB, CKMT1A and 1 morecytosolOne of 3 routes

• L-phenylalanineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and phenylalanine (cytosol to extracellular)

  Catalysed by GATM, SLC7A6cytosol, extracellular spaceOne of 13 routes

• L-tyrosineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by GATM, AADATcytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)

  Catalysed by GATM, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• 5-guanidino-2-oxopentanoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by GATM, IL4I1cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by GATM, GLYATL2cytosolOne of 2 routes

• 4-aminobutanoateReach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC6A12extracellular space, cytosolOne of 4 routes

• N-benzoylglycineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. Hippurate (Benzoylglycinate) Formation

  Catalysed by GATMcytosol, mitochondrial matrixOne of 2 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by GATM, NOS3, NOS1, NOS2cytosol