prostaglandin F2alpha

1. 15-keto-prostaglandin F2alpha reduction
2. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

No catalyst recordedcytosol, extracellular spaceOne of 2 routes

1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
2. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

Catalysed by SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
2. gamma-glutamyltransferase (alanine)

Catalysed by SLCO2A1, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. prostaglandin-F synthase (prostaglandin F2alpha)
2. thromboxane A synthase (12(S)-HHT)

Catalysed by TBXAS1cytosolOne of 2 routes

1. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)
2. glutarate + succinyl-CoA = glutaryl-CoA + succinate

Catalysed by SLC22A8, SUGCTinner side of the membrane, outer side of the membraneOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of prostaglandin E1 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 6 routes

1. carbonyl reductase (NADPH) (prostaglandin F2alpha)
2. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

Catalysed by CBR3, CBR1, AKR1C3, DHRS4 and 1 morecytosolOne of 2 routes

1. prostaglandin-F synthase (prostaglandin F2alpha)
2. prostaglandin I2 synthase (prostaglandin H2)

Catalysed by PTGIScytosol, endoplasmic reticulumOne of 7 routes

1. aldo-keto reductase (prostaglandin D2)
2. 15-dehydro-prostaglandin D2 reduction

Catalysed by AKR1C3cytosolOne of 2 routes

1. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
2. Glutathione: 15-HPETE oxidoreductase

Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosol

1. prostaglandin-F synthase (prostaglandin F2alpha)
2. thromboxane A synthase (prostaglandin H2)

Catalysed by TBXAS1cytosol, endoplasmic reticulumOne of 2 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of leukotriene A4 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

1. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

Catalysed by SLCO2A1, GLO1, GLOD4extracellular space, cytosolOne of 2 routes

1. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
2. alcohol dehydrogenase (formaldehyde)

Catalysed by SLCO2A1, ADH1C, ADH1A, ADH5 and 3 moreextracellular space, cytosol

1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
2. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

Catalysed by SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of leukotriene C4 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 6 routes

1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
2. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

Catalysed by SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
2. Glutathione: 5-HPETE oxidoreductase

Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 13 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of histamine (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)
2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

Catalysed by SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 4 routes

1. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
2. Sulfide:glutathione,quinone oxidoreductase

Catalysed by SLCO2A1, SQORextracellular space, cytosol, mitochondrial matrix

1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

Catalysed by SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of dopamine (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. prostaglandin F2alpha(out) + 2 (S)-lactate(in) = prostaglandin F2alpha(in) + 2 (S)-lactate(out)
2. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

Catalysed by SLCO2A1, PGPinner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of estrone 3-sulfate (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
2. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

Catalysed by SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
2. glutathione gamma-glutamylaminopeptidase

Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 3 moreextracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of noradrenaline (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of prostaglandin G2 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

1. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)
2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

Catalysed by SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

1. aldo-keto reductase (prostaglandin D2)
2. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

Catalysed by AKR1C3, AKR1C2cytosol

1. prostaglandin-F synthase (prostaglandin F2alpha)
2. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

Catalysed by TBXAS1, CYP2S1, PTGES2cytosol

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 6 routes

1. prostaglandin-F synthase (prostaglandin F2alpha)
2. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP4F8cytosol

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3extracellular space, cytosolOne of 4 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of arachidonate (cytosol to extracellular)
3. Utilized Transport

Catalysed by SLCO1B1extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

1. transport of prostaglandin F2alpha (cytosol to extracellular)
2. transport of serotonin (cytosol to extracellular)
3. acetyl-CoA:aralkylamine N-acetyltransferase

Catalysed by SLCO1B1, SLCO1A2