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Proteins/UNIPROT:Q9H7Z7
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity)..
Function from UniProtKB (Q9H7Z7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
64 statements
64 statements · 6 reference databases · Subject: PTGES2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
prostaglandin H2prostaglandin E2
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageLeft to rightBalancedEC 5.3.99.3cytosol
Human-GEM MAR01312CC BY 4.0Reference data
prostaglandin E1prostaglandin H1
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3cytosol
8 names
Resolves to: PTGES2
MAM02716cprostaglandin E3
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3cytosol
Human-GEM MAR02583CC BY 4.0Reference data
MAM02716nprostaglandin E3
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3nucleus
Human-GEM MAR02584CC BY 4.0Reference data
prostaglandin E2prostaglandin H2
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3endoplasmic reticulum
Human-GEM MAR08560CC BY 4.0Reference data
prostaglandin H2prostaglandin E2
Catalysed by PTGES or PTGES3 or PTGES2
Reaction pageLeft to rightBalanced
Rhea RHEA:12893CC BY 4.0Reference data
prostaglandin H2(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate+malonaldehyde
Catalysed by TBXAS1 or CYP2S1 or PTGES2
Reaction pageLeft to rightBalanced
Rhea RHEA:48644CC BY 4.0Reference data