all-trans-13,14-dihydroretinol

Three steps

• selenophosphateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. hydrogenselenide + ATP + H2O = selenophosphate + AMP + phosphate + 2 H(+)

  Catalysed by RETSAT, SCLY, SEPHS1, SEPHS2

• sulfateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
  3. Steryl-Sulfatase

  Catalysed by RETSAT, DIO1, STSGolgi apparatusOne of 3 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. all-trans-Retinol 11-cis-trans-isomerase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by RETSAT, DGAT1, LRAT, AWAT1 and 2 morecytosolOne of 2 routes

• L-cystineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by RETSAT, SCLY, SLC7A9, SLC3A1extracellular space, cytosol

• nitriteReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
  3. 4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)

  Catalysed by RETSAT, SUOX, CP

• (R)-3-aminoisobutyric acidReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by RETSAT, SCLY, AGXT2mitochondrial matrix

• L-citrullineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and citrulline (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC7A6extracellular space, cytosolOne of 4 routes

• L-valineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and valine (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC7A5extracellular space, cytosolOne of 9 routes

• oxaloacetateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. (R)-malate + A = oxaloacetate + AH2

  Catalysed by RETSAT, D2HGDH

• L-arginineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and arginine (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC7A6extracellular space, cytosolOne of 8 routes

• protein polypeptide chainReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. PROTEIN_BS

  Catalysed by RETSAT, SCLYcytosolOne of 2 routes

• CHEBI:16633Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by RETSAT, SCLYcytosol

• Met-tRNA(Met)Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by RETSAT, CDK5RAP1, MARS1cytosol

• (S)-lactateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
  3. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)

  Catalysed by RETSAT, PTGS1, PTGS2, SLCO2A1inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by RETSAT, CDK5RAP1, AADAT

• formaldehydeReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

  Catalysed by RETSAT, KDM1A, KDM1BOne of 3 routes

• CHEBI:16856Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by RETSAT, DIO1, DIO2, SLCO1A2 and 1 moreextracellular space, cytosolOne of 5 routes

• CHEBI:16857Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC7A5extracellular space, cytosolOne of 7 routes

• sn-glycerol 3-phosphocholineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. Lecithin Retinol Acyltransferase
  3. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase

  Catalysed by RETSAT, LRAT, LYPLA1, LYPLA2 and 8 morecytosolOne of 6 routes

• L-isoleucineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC7A5extracellular space, cytosolOne of 6 routes

• CHEBI:17203Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC7A5extracellular space, cytosolOne of 6 routes

• a monoacylglycerolReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
  3. a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)

  Catalysed by RETSAT, PNPLA4, PNPLA2, DDHD2 and 1 more

• L-cysteineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by RETSAT, MOCOSOne of 19 routes

• diiodineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by RETSAT, DIO1, DIO3, TPOcytosolOne of 2 routes

• nitrateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
  3. Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate

  Catalysed by RETSAT, SUOX, CYGB

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. aryl sulfotransferase (PAPS)

  Catalysed by RETSAT, DIO1, DIO2, SULT1A3 and 3 morecytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by RETSAT, SCLY, AARS1cytosol

• CHEBI:17895Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC7A5extracellular space, cytosolOne of 8 routes

• 7alpha-hydroxycholest-4-en-3-oneReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. Cholest-5-Ene-3Beta, 7Alpha-Diol:NAD+ 3-Oxidoreductase Bile Acid Biosynthesis

  Catalysed by RETSAT, CH25H, HSD3B7endoplasmic reticulum

• CHEBI:18019Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC7A6extracellular space, cytosolOne of 4 routes

• L-glutamineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and glutamine (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 12 routes

• CHEBI:18095Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. Transport of Hydroxy-Proline

  Catalysed by RETSAT, SCLY, SLC1A4extracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by RETSAT, CDK5RAP1, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by RETSAT, SCLY, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

• 11-cis-retinyl esterReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. all-trans-Retinol 11-cis-trans-isomerase
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by RETSAT, AWAT2cytosol

• 13-cis-retinyl esterReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. retinol binding protein (retinol)
  3. 13-cis-retinol + a fatty acyl-CoA = 13-cis-retinyl ester + CoA

  Catalysed by RETSAT, RBP1, RBP2, AWAT2cytosol

• 9-cis-retinyl esterReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. retinol binding protein (retinol)
  3. 9-cis-retinol + a fatty acyl-CoA = 9-cis-retinyl ester + CoA

  Catalysed by RETSAT, RBP1, RBP2, AWAT2cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by RETSAT, SCLY, AGXT2

• pyridoxine 5'-phosphateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by RETSAT, SCLYcytosol

• a fatty acidReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. Lecithin Retinol Acyltransferase
  3. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)

  Catalysed by RETSAT, LRAT, RPE65cytosolOne of 3 routes

• hypoioditeReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by RETSAT, DIO1, DIO3, MPO and 1 more

• chlorine(.)Reach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by RETSAT, SCLY, SLC6A14extracellular space, cytosolOne of 5 routes

• L-aspartateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by RETSAT, SCLY, AGXT2One of 3 routes

• (9Z)-octadecenoateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
  3. di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)

  Catalysed by RETSAT, PNPLA4, PNPLA2, DDHD2 and 1 more

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by RETSAT, CDK5RAP1, IL4I1cytosol

• D-cysteineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by RETSAT, SCLY, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by RETSAT, SCLY, SLC7A10inner side of the membrane, outer side of the membraneOne of 6 routes

• all-trans-retinoateReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. retinol: NADP+ oxidoreductase
  3. all-trans-retinal + NAD(+) + H2O = all-trans-retinoate + NADH + 2 H(+)

  Catalysed by RETSAT, DHRS3, RDH10, RDH11 and 8 morecytosolOne of 2 routes

• fatty acidReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. Lecithin Retinol Acyltransferase
  3. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase

  Catalysed by RETSAT, LRAT, LYPLA1, LYPLA2 and 8 morecytosolOne of 3 routes

• 7alpha,25-dihydroxycholesterolReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. cytochrome P450 (25-hydroxycholesterol)

  Catalysed by RETSAT, CH25H, CYP7B1endoplasmic reticulumOne of 2 routes