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all-trans-retinoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

5 compounds within 3 steps: 3 in 1, 2 in 2, 0 in 3

Does it reach a compound?

One step

all-trans-4-hydroxyretinoateReach from here →
1. all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP3A4, CYP2C8, CYP3A5, CYP3A7 and 5 more
all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →
1. all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP
Catalysed by UGT2B7
all-trans-18-hydroxyretinoateReach from here →
1. all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-18-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP26A1, CYP3A7, CYP26B1

Two steps

all-trans-4-oxoretinoateReach from here →
1. all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
2. cytochrome P450 (4-hydroxy-all-trans-retinoate)
Catalysed by CYP3A4, CYP2C8, CYP3A5, CYP3A7 and 5 morecytosolOne of 3 routes
all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoateReach from here →
1. all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
2. all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + UDP + H(+)
Catalysed by CYP3A4 and 6 more