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Proteins/UNIPROT:Q8TC12
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol. Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal. Has no dehydrogenase activity towards steroid..
Function from UniProtKB (Q8TC12), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
126 statements
126 statements · 7 reference databases · Subject: RDH11 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
9-cis-retinol+NADP(3-)9-cis-retinal+proton+NADPH(4-)
Catalysed by RDH11 or RDH8 or RDH12 or RDH13 or SDR16C5 or RDH14
Reaction pageLeft to rightBalancedEC 1.1.1.105cytosol
Human-GEM MAR01690CC BY 4.0Reference data
9 names
Resolves to: RDH11
Reaction pageLeft to rightBalancedEC 1.1.1.300cytosol
Human-GEM MAR06630CC BY 4.0Reference data
NADP(3-)+all-trans-retinolproton+NADPH(4-)+all-trans-retinal
Catalysed by RDH11 or DHRS9 or RDH8 or RDH10 or RDH12 or DHRS3
Reaction pageLeft to rightBalancedEC 1.1.1.300endoplasmic reticulum
Human-GEM MAR06632CC BY 4.0Reference data
all-trans-retinol+NADP(3-)all-trans-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or DHRS3 or AKR1B1 or RDH10 or RDH13 or RDH11 or RDH12 or RDH14 or RDH8 or DHRS7
Reaction pageRight to leftBalanced
Rhea RHEA:25033CC BY 4.0Reference data
11-cis-retinol+NADP(3-)11-cis-retinal+NADPH(4-)+hydron
Catalysed by RDH11 or RDH12 or RDH14
Reaction pageDirection not assertedBalanced
Rhea RHEA:54912CC BY 4.0Reference data
9-cis-retinol+NADP(3-)9-cis-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or AKR1B1 or AKR1C3 or RDH11 or RDH12 or RDH14
Reaction pageRight to leftBalanced
Rhea RHEA:54916CC BY 4.0Reference data
13-cis-retinol+NADP(3-)13-cis-retinal+NADPH(4-)+hydron
Catalysed by AKR1B10 or AKR1B1 or RDH11
Reaction pageDirection not assertedBalanced
Rhea RHEA:54920CC BY 4.0Reference data