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Proteins/UNIPROT:O94830
Diacylglycerol (DAG) and triacylglycerol (TAG) lipase required for proper lipid homeostasis in the central nervous system. It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3 DAG downstream of PNPLA2/ATGL (By similarity). In vitro, it also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane..
Function from UniProtKB (O94830), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
93 statements
93 statements · 5 reference databases · Subject: DDHD2 · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, Rhea
15 reactions
a triacylglycerol+watera diacylglycerol+a fatty acid+hydron
Catalysed by DDHD2 or LPL or LIPF or ABHD2 or LIPC or PNLIP or CEL or AADAC or PNPLA4 or PNLIPRP2 or LIPE or PNLIPRP3 and 7 more alternatives
9 names
Resolves to: DDHD2
Rhea RHEA:12044CC BY 4.0Reference data
a diacylglycerol+watera monoacylglycerol+a fatty acid+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32731CC BY 4.0Reference data
a 1-acylglycerol+waterglycerol+a fatty acid+hydron
Catalysed by DDHD2 or MGLL or ABHD6 or ABHD16B
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:34019CC BY 4.0Reference data
1-(9Z-octadecenoyl)-glycerol+waterglycerol+(9Z)-octadecenoate+hydron
Catalysed by DDHD2 or ABHD16A or PNLIPRP2 or LIPE or PLB1 or PNPLA6 or ABHD12 or MGLL or ABHD6 or ABHD16B
Reaction pageLeft to rightBalanced
Rhea RHEA:38487CC BY 4.0Reference data
1,2,3-tri-(9Z-octadecenoyl)-glycerol+waterdi-(9Z)-octadecenoylglycerol+(9Z)-octadecenoate+hydron
Catalysed by DDHD2 or LPL or LIPC or PNLIP or CEL or PNLIPRP2 or LIPE or PLB1 or LIPG
Reaction pageLeft to rightBalanced
Rhea RHEA:38575CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron
Catalysed by DDHD2 or LPL or LIPC or DDHD1
Reaction pageLeft to rightBalanced
Rhea RHEA:38699CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by DDHD2 or PLAAT3 or PLA2G4F or PLA2G15 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:38783CC BY 4.0Reference data
1,3-di-(9Z-octadecenoyl)-glycerol+water1-(9Z-octadecenoyl)-glycerol+(9Z)-octadecenoate+hydron
Catalysed by DDHD2 or LIPA or LIPE or PLB1
Reaction pageLeft to rightBalanced
Rhea RHEA:39939CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate+water2-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hexadecanoate+hydron
Catalysed by DDHD2 or LIPI or DDHD1 or LIPH
Reaction pageLeft to rightBalanced
Rhea RHEA:40943CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine+water2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine+hexadecanoate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:43968CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+water2-(9Z-octadecenoyl)-sn-glycero-3-phosphate+(9Z)-octadecenoate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:45128CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+water2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+hexadecanoate+hydron
Catalysed by DDHD2
Reaction pageLeft to rightBalanced
Rhea RHEA:45132CC BY 4.0Reference data