(S)-lactic acid

1. transport of acetoacetate and L-lactate (cytosol to extracellular)
2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

1. transport of L-lactate and urate (cytosol to extracellular)
2. urate:oxygen oxidoreductase

Catalysed by SLC22A12extracellular space, cytosol

1. (S)-Lactate:NAD+ oxidoreductase
2. pyruvate kinase (dTDP)

Catalysed by LDHB, LDHAL6B, PKM, PKLRmitochondrial matrix, cytosol

1. (S)-Lactate:NAD+ oxidoreductase
2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

Catalysed by LDHB, LDHAL6B, AGXT2mitochondrial matrix

1. (S)-Lactate:NAD+ oxidoreductase
2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

Catalysed by LDHB, LDHAL6B, AGXT2mitochondrial matrix

1. (S)-Lactate:NAD+ oxidoreductase
2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

Catalysed by LDHB, LDHAL6B, AGXT2mitochondrial matrix

1. transport of acetate and L-lactate (cytosol to extracellular)
2. cytochrome P450 (17alpha-hydroxypregnenolone)

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol, endoplasmic reticulum

1. transport of L-lactate and urate (cytosol to extracellular)
2. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

Catalysed by SLC22A12, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of formate and L-lactate (cytosol to extracellular)
2. transport of chloride and formate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

1. (S)-Lactate:NAD+ oxidoreductase
2. L-Serine:pyruvate aminotransferase

Catalysed by LDHB, LDHAL6B, AGXTmitochondrial matrix, cytosolOne of 2 routes

1. transport of L-lactate and urate (cytosol to extracellular)
2. urate(in) + glutarate(out) = urate(out) + glutarate(in)

Catalysed by SLC22A12, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of L-lactate and urate (cytosol to extracellular)
2. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

Catalysed by SLC22A12, SLC22A13extracellular space, cytosol, inner side of the membrane, outer side of the membrane

1. (S)-Lactate:NAD+ oxidoreductase
2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

Catalysed by LDHB, LDHAL6B, AGXT2mitochondrial matrix

1. (S)-Lactate:NAD+ oxidoreductase
2. D-serine = pyruvate + NH4(+)

Catalysed by LDHB, LDHAL6B, SRRmitochondrial matrix

1. (S)-Lactate:NAD+ oxidoreductase
2. (R)-Lactate:NAD+ oxidoreductase

Catalysed by LDHB, LDHAL6B, LDHDmitochondrial matrix, cytosol

1. transport of acetoacetate and L-lactate (cytosol to extracellular)
2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol

1. (S)-Lactate:NAD+ oxidoreductase
2. 2-iminopropanoate + H2O = pyruvate + NH4(+)

Catalysed by LDHB, LDHAL6B, RIDAmitochondrial matrix

1. (S)-Lactate:NAD+ oxidoreductase
2. pyruvate kinase (dTDP)

Catalysed by LDHB, LDHAL6B, PKM, PKLRmitochondrial matrix, cytosol

1. transport of L-lactate and retinoate (cytosol to extracellular)
2. retinal dehydrogenase (13-cis-retinal)

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol, endoplasmic reticulum

1. (S)-Lactate:NAD+ oxidoreductase
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

Catalysed by LDHB, LDHAL6B, NPLmitochondrial matrix, cytosol

1. transport of acetate and L-lactate (cytosol to extracellular)
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

1. (S)-Lactate:NAD+ oxidoreductase
2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

Catalysed by LDHB, LDHAL6B, FAHD1mitochondrial matrix

1. transport of acetoacetate and L-lactate (cytosol to extracellular)
2. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosolOne of 2 routes

1. transport of butyrate and L-lactate (cytosol to extracellular)
2. Butanoate:CoA ligase (AMP-forming)

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 8 moreextracellular space, cytosolOne of 2 routes

1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
2. Formation of Prostaglandin I2

No catalyst recordedextracellular space, cytosol

1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
2. 15-keto-prostaglandin F2alpha reduction

No catalyst recordedextracellular space, cytosolOne of 2 routes

1. Transport of Prostaglandin J2, Lactate Antiport
2. prostaglandin J2 hydrolysis

No catalyst recordedextracellular space, cytosolOne of 2 routes

1. (S)-Lactate:ferricytochrome-c 2-oxidoreductase
2. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

Catalysed by CYB5D1mitochondrial matrix, cytosol

1. transport of acetate and L-lactate (cytosol to extracellular)
2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

1. (S)-Lactate:NAD+ oxidoreductase
2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

Catalysed by LDHB, LDHAL6B, MPSTmitochondrial matrix

1. (S)-Lactate:NAD+ oxidoreductase
2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

Catalysed by LDHB, LDHAL6B, AGXT2mitochondrial matrix

1. (S)-Lactate:NAD+ oxidoreductase
2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

Catalysed by LDHB, LDHAL6B, TYW1B, TYW1mitochondrial matrix

1. transport of L-lactate and urate (cytosol to extracellular)
2. urate(out) + glutathione(in) = urate(in) + glutathione(out)

Catalysed by SLC22A12, SLC22A13extracellular space, cytosol, inner side of the membrane, outer side of the membrane

1. (S)-Lactate:NAD+ oxidoreductase
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by LDHB, LDHAL6B, AGXT2mitochondrial matrixOne of 18 routes

1. transport of acetate and L-lactate (cytosol to extracellular)
2. N-acetylputrescine + H2O = putrescine + acetate

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

1. transport of acetate and L-lactate (cytosol to extracellular)
2. N(8)-acetylspermidine + H2O = spermidine + acetate

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

1. (S)-Lactate:NAD+ oxidoreductase
2. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

Catalysed by LDHB, LDHAL6B, CLYBLmitochondrial matrix

1. transport of acetate and L-lactate (cytosol to extracellular)
2. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

1. (S)-Lactate:NAD+ oxidoreductase
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

Catalysed by LDHB, LDHAL6B, AGXT2mitochondrial matrix

1. Transport of Prostaglandin A2, Lactate Antiport
2. scavenger receptor class F (prostaglandin A2)

Catalysed by SCARF2extracellular space, cytosolOne of 2 routes

1. (S)-Lactate:NAD+ oxidoreductase
2. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Catalysed by LDHB, LDHAL6B, HOGA1mitochondrial matrix

1. (S)-Lactate:NAD+ oxidoreductase
2. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Catalysed by LDHB, LDHAL6B, HOGA1mitochondrial matrix

1. transport of L-lactate and urate (cytosol to extracellular)
2. Peroxidase

Catalysed by SLC22A12, MPOextracellular space, cytosol, nucleusOne of 3 routes

1. (S)-Lactate:NAD+ oxidoreductase
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

Catalysed by LDHB, LDHAL6B, PDHA1, PDHB and 1 moremitochondrial matrix

1. transport of formate and L-lactate (cytosol to extracellular)
2. transport of chloride and formate (cytosol to extracellular)
3. Carnitine Transport by Atb0

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosolOne of 5 routes

1. (S)-Lactate:NAD+ oxidoreductase
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)