5,6,7,8-tetrahydrofolic acid

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. glycine N-acyltransferase (2-methylbutyryl-CoA)

Catalysed by SHMT1, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
2. dihydrofolate:NAD+ oxidoreductase

Catalysed by DHFR, DHFR2cytosolOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

Catalysed by SHMT1, GLYATcytosolOne of 3 routes

1. histamine N-methyltransferase (SAM)
2. Methionine Synthase

Catalysed by HNMTcytosol, nucleusOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. LTD4 hydrolysis

Catalysed by SHMT1cytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. glycine:tRNA(Gly) ligase (AMP-forming)

Catalysed by SHMT1, GARS1cytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of chloride and glycine (cytosol to extracellular)

Catalysed by SHMT1, SLC6A9, SLC6A14cytosol, extracellular spaceOne of 3 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by SHMT1, BAATcytosol, peroxisomeOne of 3 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

Catalysed by SHMT1, ALAS1, ALAS2cytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

Catalysed by SHMT1, BAATcytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by SHMT1, BAATcytosol, peroxisomeOne of 3 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

Catalysed by SHMT1, AADATcytosolOne of 11 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA:amino acid N-acyltransferase (glycine)

Catalysed by SHMT1, BAATcytosolOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. Acetyl-CoA:glycine C-acetyltransferase

Catalysed by SHMT1, GCATcytosol, mitochondrial matrix

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. L-Arginine:glycine amidinotransferase

Catalysed by SHMT1, GATMcytosolOne of 5 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

Catalysed by SHMT1, GLDC, GCSHcytosol, mitochondrial matrix

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

Catalysed by SHMT1, PIPOXcytosolOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

Catalysed by SHMT1, SHMT2cytosolOne of 3 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase

Catalysed by SHMT1, MTHFD2, MTHFD2Lcytosol, mitochondrial matrixOne of 8 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

Catalysed by SHMT1, GLYATL3, GLYAT, GLYATL2cytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. L-Arginine:glycine amidinotransferase

Catalysed by SHMT1, GATMcytosolOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of glycine and methionine (cytosol to extracellular)

Catalysed by SHMT1, SLC7A5cytosol, extracellular spaceOne of 6 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of glycine and tryptophan (cytosol to extracellular)

Catalysed by SHMT1, SLC7A5cytosol, extracellular spaceOne of 5 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

Catalysed by SHMT1, GSScytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of alanine and glycine (cytosol to extracellular)

Catalysed by SHMT1, SLC3A2, SLC7A5, SLC7A10cytosol, extracellular spaceOne of 6 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. leukotriene C4 hydrolysis

Catalysed by SHMT1cytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of asparagine and glycine (cytosol to extracellular)

Catalysed by SHMT1cytosol, extracellular spaceOne of 4 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of glycine and phenylalanine (cytosol to extracellular)

Catalysed by SHMT1, SLC7A5cytosol, extracellular spaceOne of 7 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

Catalysed by SHMT1, AADATcytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

Catalysed by SHMT1, AGXT2cytosol

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
2. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

Catalysed by ATIC, ADSLcytosolOne of 2 routes

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
2. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

Catalysed by ATICcytosolOne of 2 routes

1. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
2. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

Catalysed by FTCDcytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2cytosolOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. Hippurate (Benzoylglycinate) Formation

Catalysed by SHMT1cytosol, mitochondrial matrixOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase

Catalysed by SHMT1, TYMScytosol

1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
2. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

Catalysed by ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

Catalysed by SHMT1, AGXT2cytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. Glycodeoxycholate amidohydrolase

Catalysed by SHMT1cytosolOne of 2 routes

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2cytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by SHMT1, BAATcytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by SHMT1, BAATcytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by SHMT1, BAATcytosol

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of glycine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by SHMT1, SLC7A5cytosol, extracellular space

1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Carnitine O-Palmitoyltransferase

Catalysed by SHMT1, BAAT and 1 more